Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Mayo Clin Proc. 2021 Sep;96(9):2354-2365. doi: 10.1016/j.mayocp.2021.01.031. Epub 2021 Aug 5.
To determine whether the Mayo Cardiac Intensive Care Unit (CICU) Admission Risk Score (M-CARS) accurately predicts 1-year mortality.
We retrospectively reviewed adult CICU patients admitted from January 1, 2007, through April 30, 2018, and calculated M-CARS using admission data. We examined the association between admission M-CARS, as continuous and categorical variables, and 1-year mortality.
This study included 12,428 unique patients with a mean age of 67.6±15.2 years (4686 [37.7%] female). A total of 2839 patients (22.8%) died within 1 year of admission, including 1149 (9.2%) hospital deaths and 1690 (15.0%) of the 11,279 hospital survivors. The 1-year survival decreased incrementally as a function of increasing M-CARS (P<.001), and all components of M-CARS were significant predictors of 1-year mortality (P<.001). The 1-year survival among hospital survivors decreased incrementally as a function of increasing M-CARS for scores below 3 (all P<.001); however, there was no further decrease in 1-year survival for hospital survivors with M-CARS of 3 or more (P=.99). The M-CARS components associated with 1-year mortality among hospital survivors included blood urea nitrogen, red blood cell distribution width, Braden skin score, and respiratory failure (all P<.001).
M-CARS predicted 1-year mortality among CICU admissions, with a plateau effect at high M-CARS of 3 or more for hospital survivors. Significant added predictors of 1-year mortality among hospital survivors included markers of frailty and chronic illness.
确定梅奥心脏重症监护病房(CICU)入院风险评分(M-CARS)是否能准确预测 1 年死亡率。
我们回顾性分析了 2007 年 1 月 1 日至 2018 年 4 月 30 日期间入住成人 CICU 的患者,并使用入院数据计算 M-CARS。我们检验了入院 M-CARS(连续变量和分类变量)与 1 年死亡率之间的关系。
本研究共纳入 12428 例患者,平均年龄 67.6±15.2 岁(4686[37.7%]例为女性)。共有 2839 例(22.8%)患者在入院后 1 年内死亡,包括 1149 例(9.2%)院内死亡和 1690 例(15.0%)11279 例院内存活患者。随着 M-CARS 的增加,1 年生存率逐渐降低(P<.001),M-CARS 的所有组成部分都是 1 年死亡率的显著预测因素(P<.001)。对于 M-CARS 评分低于 3 的住院幸存者,随着 M-CARS 的增加,1 年生存率逐渐降低(均 P<.001);然而,对于 M-CARS 评分≥3 的住院幸存者,1 年生存率无进一步下降(P=.99)。与住院幸存者 1 年死亡率相关的 M-CARS 组成部分包括血尿素氮、红细胞分布宽度、Braden 皮肤评分和呼吸衰竭(均 P<.001)。
M-CARS 预测了 CICU 入院患者的 1 年死亡率,对于 M-CARS 评分≥3 的住院幸存者,死亡率呈平台效应。对于住院幸存者 1 年死亡率的显著附加预测因素包括脆弱和慢性疾病的标志物。