用于筛查阿尔茨海默病的视网膜淀粉样蛋白成像
Retinal Amyloid Imaging for Screening Alzheimer's Disease.
作者信息
Tadokoro Koh, Yamashita Toru, Kimura Shuhei, Nomura Emi, Ohta Yasuyuki, Omote Yoshio, Takemoto Mami, Hishikawa Nozomi, Morihara Ryuta, Morizane Yuki, Abe Koji
机构信息
Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan.
Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan.
出版信息
J Alzheimers Dis. 2021;83(2):927-934. doi: 10.3233/JAD-210327.
BACKGROUND
Cost-effective and noninvasive methods for in vivo imaging of amyloid deposition are needed to screen Alzheimer's disease (AD). Although retinal amyloid is a possible diagnostic marker of AD, there are very few studies on in vivo retinal amyloid imaging.
OBJECTIVE
To examine the usefulness of in vivo imaging of retinal amyloid in AD patients.
METHODS
To examine amyloid deposition, 30 Japanese subjects (10 normal control (NC), 7 with mild cognitive impairment (MCI), and 13 with AD) underwent a complete ophthalmic examination, including fundus imaging by scanning laser ophthalmoscopy before and after oral curcumin intake.
RESULTS
Retinal amyloid deposition was greater in AD than in NC subjects (*p < 0.05) while MCI showed a slight but insignificant increase of retinal amyloid deposition relative to NC subjects. Retinal amyloid deposition was correlated with whole gray matter atrophy (r = 0.51, *p < 0.05) but not with the cognitive score of the Mini-Mental State Examination, nor with medial temporal lobe atrophy.
CONCLUSION
The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening AD patients.
背景
需要具有成本效益且无创的方法来对淀粉样蛋白沉积进行体内成像，以筛查阿尔茨海默病（AD）。尽管视网膜淀粉样蛋白可能是AD的一种诊断标志物，但关于体内视网膜淀粉样蛋白成像的研究非常少。
目的
研究视网膜淀粉样蛋白体内成像在AD患者中的实用性。
方法
为检测淀粉样蛋白沉积，30名日本受试者（10名正常对照（NC）、7名轻度认知障碍（MCI）患者和13名AD患者）接受了全面的眼科检查，包括口服姜黄素前后通过扫描激光检眼镜进行眼底成像。
结果
AD患者的视网膜淀粉样蛋白沉积比NC受试者更多（*p<0.05），而MCI患者相对于NC受试者，视网膜淀粉样蛋白沉积有轻微增加，但无统计学意义。视网膜淀粉样蛋白沉积与全脑灰质萎缩相关（r=0.51，*p<0.05），但与简易精神状态检查的认知评分无关，也与内侧颞叶萎缩无关。
结论
目前这种无创的视网膜淀粉样蛋白沉积体内检测方法对筛查AD患者有用。
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