CPNE家族及其在癌症中的作用。
The CPNE Family and Their Role in Cancers.
作者信息
Tang Haicheng, Pang Pei, Qin Zhu, Zhao Zhangyan, Wu Qingguo, Song Shu, Li Feng
机构信息
Department of Respiratory and Critical Care Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China.
出版信息
Front Genet. 2021 Jul 23;12:689097. doi: 10.3389/fgene.2021.689097. eCollection 2021.
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in cancer research and treatment, the overall prognosis of lung cancer patients remains poor. Therefore, the identification for novel therapeutic targets is critical for the diagnosis and treatment of lung cancer. CPNEs (copines) are a family of membrane-bound proteins that are highly conserved, soluble, ubiquitous, calcium dependent in a variety of eukaryotes. Emerging evidences have also indicated CPNE family members are involved in cancer development and progression as well. However, the expression patterns and clinical roles in cancer have not yet been well understood. In this review, we summarize recent advances concerning CPNE family members and provide insights into new potential mechanism involved in cancer development.
肺癌是全球癌症相关死亡的主要原因。尽管癌症研究和治疗取得了重大进展，但肺癌患者的总体预后仍然很差。因此，确定新的治疗靶点对于肺癌的诊断和治疗至关重要。Copine（CPNE）蛋白是一类膜结合蛋白，在多种真核生物中高度保守、可溶、普遍存在且依赖钙。新出现的证据也表明CPNE家族成员也参与癌症的发生和发展。然而，其在癌症中的表达模式和临床作用尚未得到充分了解。在这篇综述中，我们总结了关于CPNE家族成员的最新进展，并深入探讨了参与癌症发展的新潜在机制。
Zotero 插件