Ge Ya-Ru, Huan Na, Wang Cheng-Long, Wang Pei-Li
Center for Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Evid Based Complement Alternat Med. 2021 Jul 29;2021:5563987. doi: 10.1155/2021/5563987. eCollection 2021.
Antiplatelet therapy is the key point in the treatment of cardiovascular and cerebrovascular diseases. Effective and safe antiplatelet therapy can avoid the risk of thrombosis or bleeding again. Herbal and Western medicine combined with antiplatelet therapy for ischemic cardiovascular events is a common phenomenon in clinical application, and more and more animal experiments, in vitro cell experiments, and randomized controlled clinical studies have also clarified the efficacy and interaction mechanism of the combination and safety. Herbal and Western medicine combined with antiplatelet therapy has made some progress in improving aspirin resistance and clopidogrel resistance, enhancing antiplatelet and antithrombotic effect, and reducing gastrointestinal adverse reactions caused by antiplatelet drugs. Both of them play the role of antiplatelet and antithrombotic by reducing platelet adhesion, inhibiting platelet activation and aggregation, and inhibiting platelet release, and the combination of drugs is safe. This article elaborates and analyzes the application progress and prospect of Chinese and Western medicine combined with antiplatelet therapy, in order to provide more theoretical support for future research.
抗血小板治疗是心脑血管疾病治疗的关键环节。有效且安全的抗血小板治疗可避免再次发生血栓形成或出血的风险。中药与西药联合抗血小板治疗缺血性心血管事件在临床应用中较为常见，越来越多的动物实验、体外细胞实验及随机对照临床研究也阐明了联合用药的疗效、相互作用机制及安全性。中药与西药联合抗血小板治疗在改善阿司匹林抵抗和氯吡格雷抵抗、增强抗血小板及抗血栓作用、减少抗血小板药物引起的胃肠道不良反应等方面取得了一定进展。二者均通过降低血小板黏附、抑制血小板活化与聚集以及抑制血小板释放来发挥抗血小板和抗血栓作用，且联合用药安全。本文阐述并分析了中西医联合抗血小板治疗的应用进展及前景，以期为未来研究提供更多理论支持。
