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病例报告:重症监护中无意识 COVID-19 患者的脑血栓栓塞。

Case report: cerebral thromboembolism in an unconscious COVID-19 patient in intensive care.

机构信息

Department of Chest Disease, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.

Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.

出版信息

Pan Afr Med J. 2021 Apr 15;38:373. doi: 10.11604/pamj.2021.38.373.29034. eCollection 2021.

Abstract

Although the severity of coronavirus disease 2019 (COVID-19) being more frequently related to acute respiratory distress syndrome and acute cardiac and renal injuries, thromboembolic events have been increasingly reported. Acute respiratory distress syndrome due to SARS-CoV-2 (Severe Acute Respiratory Syndrome - Corona Virus 2) often requires intensive care follow-up. As well as respiratory failure, the SARS-CoV-2 may cause central nervous system (CNS) involvement. The pandemic has raised many challenges in managing critically ill older adults, a population preferentially killed by COVID-19. The mortality and morbidity rates are extremely high in critically ill patients with COVID-19. Recent studies have reported the potential development of a hypercoagulable state in COVID-19. Viral infections and hypoxia may cause these state. It is increasingly reported that thromboembolic events are associated with a poor prognosis. Due to these thromboembolic complications, COVID-19 patients often have neurological symptoms. These symptoms may not be observed in intensive care patients who are sedated. We report one case who was sedated COVID-19 pneumonia and who was later diagnosed with cerebral venous thrombosis with cranial imaging when he could not awaken even though sedation was discontinued. Since COVID-19 causes intense thrombotic susceptibility due to cytokine storm, cerebrovascular thromboembolic complications associated with COVID-19 infection should be considered first and foremost for unconsciousness ventilated patients. Severe and potentially cerebral thrombosis may prolong the patient´s stay in intensive care.

摘要

尽管 2019 年冠状病毒病 (COVID-19) 的严重程度通常与急性呼吸窘迫综合征和急性心脏及肾脏损伤有关,但血栓栓塞事件的报道却越来越多。由 SARS-CoV-2(严重急性呼吸综合征 - 冠状病毒 2)引起的急性呼吸窘迫综合征通常需要进行重症监护随访。除了呼吸衰竭,SARS-CoV-2 还可能导致中枢神经系统 (CNS) 受累。大流行对危重病老年人的管理提出了许多挑战,这是一个优先被 COVID-19 杀死的人群。COVID-19 重症患者的死亡率和发病率极高。最近的研究报告称 COVID-19 中可能存在高凝状态。病毒感染和缺氧可能导致这种状态。越来越多的报道表明,血栓栓塞事件与预后不良有关。由于这些血栓栓塞并发症,COVID-19 患者经常出现神经系统症状。这些症状在接受镇静治疗的重症监护患者中可能观察不到。我们报告了一例 COVID-19 肺炎患者被镇静治疗,尽管停用镇静剂后仍无法苏醒,随后通过头颅成像诊断为脑静脉血栓形成。由于 COVID-19 会因细胞因子风暴而导致强烈的血栓易感性,因此与 COVID-19 感染相关的脑血管血栓栓塞并发症应首先考虑无意识通气患者。严重且可能发生的脑血栓可能会延长患者在重症监护病房的停留时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c6/8309002/31797586323f/PAMJ-38-373-g001.jpg

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