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涉及肝移植的医疗旅游现状——感染风险与潜在并发症

Current state of medical tourism involving liver transplantation-the risk of infections and potential complications.

作者信息

Neupane Ritesh, Taweesedt Pahnwat Tonya, Anjum Humayun, Surani Salim

机构信息

Department of Medicine, Penn State Health Milton S Hershey Medical Center, Hershey, PA 17033, United States.

Department of Medicine, Corpus Christi Medical Center, Corpus Christi, TX 78412, United States.

出版信息

World J Hepatol. 2021 Jul 27;13(7):717-722. doi: 10.4254/wjh.v13.i7.717.

DOI:10.4254/wjh.v13.i7.717
PMID:34367493
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8326159/
Abstract

Liver transplant has been shown to significantly improve mortality and quality of life in various liver diseases such as acute liver failure, end-stage liver disease, and liver cancer. While the organ transplant demand is continuing to rise, the organ donation supply remains unmatched. The organ shortage, high cost, and long waiting lists have stimulated a desire for routes that may be unethical. This process which is named transplant tourism is the term used to describe traveling to another country to purchase an organ for transplant. Liver transplant tourism has been associated with post-transplant complications and higher mortality compared to a domestic liver transplant. Improper pre-and post-transplant infectious screening, inadequate opportunistic infection prophylaxis, and loss to follow-up were noted in patients who travel abroad for a liver transplant. It is crucial to understand the risk of transplant tourism to prevent morbidity and mortality.

摘要

肝移植已被证明能显著提高各种肝脏疾病(如急性肝衰竭、终末期肝病和肝癌)患者的死亡率并改善其生活质量。尽管器官移植需求持续上升,但器官捐赠供应仍无法满足需求。器官短缺、高昂费用和漫长的等待名单引发了对可能不道德途径的渴望。这个被称为移植旅游的过程是指前往另一个国家购买器官用于移植。与国内肝移植相比,肝移植旅游与移植后并发症及更高的死亡率相关。在出国进行肝移植的患者中,存在移植前后感染筛查不当、机会性感染预防不足以及失访等问题。了解移植旅游的风险对于预防发病和死亡至关重要。

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本文引用的文献

1
Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review.肝移植术后10年的健康相关生活质量:一项纵向回顾性研究
Diagnostics (Basel). 2021 Jan 12;11(1):111. doi: 10.3390/diagnostics11010111.
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OPTN/SRTR 2018 Annual Data Report: Liver.OPTN/SRTR 2018 年度数据报告:肝脏。
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Liver Transplant Tourism.肝脏移植旅游。
孤立性肝细胞癌的治疗策略:基于肿瘤位置比较射频消融与腹腔镜肝切除的疗效
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Burden of liver diseases in the world.世界范围内的肝脏疾病负担。
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8
Transplantation in foreign nationals: Lower rates of waitlist mortality and higher rates of lost to follow-up posttransplant.外国人的移植:更低的等待名单死亡率和更高的移植后失访率。
Am J Transplant. 2018 Nov;18(11):2663-2669. doi: 10.1111/ajt.15005. Epub 2018 Aug 13.
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Deceased Donor Organ Transplantation Performed in the United States for Noncitizens and Nonresidents.美国为非公民和非居民进行的已故供体器官移植。
Transplantation. 2018 Jul;102(7):1124-1131. doi: 10.1097/TP.0000000000002086.
10
Changing Patterns of Foreigner Transplants in Korea and Overseas Organ Transplants Among Koreans.韩国外国人器官移植的变化模式和韩国人海外器官移植。
Transplantation. 2018 Feb;102(2):310-317. doi: 10.1097/TP.0000000000001935.