Zhao Junsheng, Yang Zhongli, Tu Mingmin, Meng Wei, Gao Hainv, Li Ming D, Li Lanjuan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Clinical Laboratory, Hangzhou Tongchuang Medical Laboratory, Hangzhou, China.
Front Oncol. 2021 Jul 22;11:608641. doi: 10.3389/fonc.2021.608641. eCollection 2021.
Solute carrier family 1 member 5 () is a major glutamine transporter and plays a key role in tumor growth. The main objectives of this study were to visualize the prognostic landscape of in multiple cancers and determine the relations between expression and tumor immunity.
expression and its effect on tumor prognosis were analyzed using multiple online tools Oncomine, Gene Expression Profiling Interactive Analysis, PrognoScan, and Kaplan-Meier plotter with their own datasets as well as the data from The Cancer Genome Atlas. The correlations between and tumor immune infiltrates were determined TIMER.
expression was significantly higher in several types of cancers, including hepatocellular carcinoma (HCC), compared with corresponding normal tissues. High expression correlated with poor overall survival and with disease-free survival related to alcohol consumption. Moreover, expression correlated positively with the numbers of tumor-infiltrating B cells, CD4 T and CD8 T cells, macrophages, neutrophils, and dendritic cells in HCC and in lower-grade glioma (LGG). Also, expression showed strong correlations with diverse immune marker sets in HCC and LGG, indicating its role in regulating tumor immunity.
represents a useful prognostic biomarker in multiple cancers, and its expression correlates highly with tumor immune-cell infiltration, especially in HCC and LGG.
溶质载体家族1成员5（）是一种主要的谷氨酰胺转运蛋白，在肿瘤生长中起关键作用。本研究的主要目的是描绘在多种癌症中的预后情况，并确定表达与肿瘤免疫之间的关系。
使用多个在线工具Oncomine、基因表达谱交互式分析、PrognoScan和Kaplan-Meier绘图仪，利用它们自己的数据集以及来自癌症基因组图谱的数据，分析表达及其对肿瘤预后的影响。通过TIMER确定与肿瘤免疫浸润之间的相关性。
与相应的正常组织相比，在包括肝细胞癌（HCC）在内的几种癌症类型中，表达显著更高。高表达与总体生存率差以及与酒精消费相关的无病生存率差相关。此外，在HCC和低级别胶质瘤（LGG）中，表达与肿瘤浸润性B细胞、CD4 T细胞和CD8 T细胞、巨噬细胞、中性粒细胞和树突状细胞的数量呈正相关。而且，在HCC和LGG中，表达与多种免疫标志物集显示出强相关性，表明其在调节肿瘤免疫中的作用。
在多种癌症中代表一种有用的预后生物标志物，其表达与肿瘤免疫细胞浸润高度相关，尤其是在HCC和LGG中。
