Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 211198, China.
Int J Mol Sci. 2023 Mar 4;24(5):4954. doi: 10.3390/ijms24054954.
Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are important components of tumor metabolic reprogramming. Mitochondria have gradually received the attention of scientists due to their important functions, such as providing chemical energy, producing substrates for tumor anabolism, controlling REDOX and calcium homeostasis, participating in the regulation of transcription, and controlling cell death. Based on the concept of reprogramming mitochondrial metabolism, a range of drugs have been developed to target the mitochondria. In this review, we discuss the current progress in mitochondrial metabolic reprogramming and summarized the corresponding treatment options. Finally, we propose mitochondrial inner membrane transporters as new and feasible therapeutic targets.
异常的能量代谢是肿瘤细胞的一个特征，线粒体是肿瘤代谢重编程的重要组成部分。由于其重要的功能，如提供化学能量、为肿瘤合成代谢产生底物、控制 REDOX 和钙稳态、参与转录调控以及控制细胞死亡等，线粒体逐渐受到科学家的关注。基于重编程线粒体代谢的概念，已经开发了一系列针对线粒体的药物。在这篇综述中，我们讨论了线粒体代谢重编程的最新进展，并总结了相应的治疗选择。最后，我们提出线粒体内膜转运蛋白作为新的可行的治疗靶点。
