肌阵挛性发作和阵挛性发作的神经体液差异调节
Differential neurohumoral modulation of myoclonic and clonic seizures.
作者信息
Greer C A, Alpern H P
出版信息
Arch Int Pharmacodyn Ther. 1978 Nov;236(1):74-85.
Differential effects of neuropharmacological drugs upon susceptibility to flurothyl-induced myoclonic and clonic convulsions were assessed in two selectively bred lines of mice. Dopaminergic drugs (apomorphine and haloperidol) only affected myoclonus, whereas cholinergic (pilocarpine and scopolamine), gabaergic (AOAA and bicuculline), and serotonergic (PCPA) compounds principally influenced clonus. Noradrenergic drugs (clonidine, phentolamine and sotalol), however, altered the expression of both types of seizures. The apparent differential neurohumoral modulation of myoclonus and clonus is discussed in light of previous suggestions that these behaviors have separate neural substrates.
在两个经过选择性培育的小鼠品系中，评估了神经药理学药物对氟乙酰胺诱导的肌阵挛性和阵挛性惊厥易感性的不同影响。多巴胺能药物（阿扑吗啡和氟哌啶醇）仅影响肌阵挛，而胆碱能（毛果芸香碱和东莨菪碱）、γ-氨基丁酸能（氨基氧乙酸和荷包牡丹碱）和5-羟色胺能（对氯苯丙氨酸）化合物主要影响阵挛。然而，去甲肾上腺素能药物（可乐定、酚妥拉明和索他洛尔）改变了两种类型惊厥的表现。根据先前关于这些行为具有独立神经基质的建议，讨论了肌阵挛和阵挛明显的神经体液调节差异。
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