Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Adv Exp Med Biol. 2021;1301:59-79. doi: 10.1007/978-3-030-62026-4_5.
Ferroptosis is a distinct form regulated necrotic cell death mainly characterized by the accumulation of toxic lipid peroxides. The importance of this form of cell death has been recognized in several diseases. An imbalance between free radicals and antioxidant molecules has been reported to play role in several pathologies and is commonly associated with worse outcomes of these maladies. Emerging evidence suggests that ferroptosis and/or its regulators may modulate other forms of cell death leading to the induction of necro-inflammatory response and consequently organ failure. Herein, we review the major forms of necrotic cell death triggered by pathogens highlighting mechanisms in which oxidative stress and cellular antioxidants may limit or favor pathogen dissemination defining host cell fate. Specially, we discuss the role of ferroptosis and how its molecular components may modulate disease progression.
铁死亡是一种受调控的坏死性细胞死亡形式，主要特征是有毒脂质过氧化物的积累。这种细胞死亡形式在几种疾病中的重要性已得到认可。自由基和抗氧化分子之间的失衡被报道在几种病理中发挥作用，并与这些疾病的不良后果密切相关。新出现的证据表明，铁死亡和/或其调节剂可能调节其他形式的细胞死亡，导致坏死性炎症反应的诱导，并最终导致器官衰竭。在此，我们综述了病原体引发的主要坏死性细胞死亡形式，强调了氧化应激和细胞内抗氧化剂如何限制或促进病原体传播，从而决定宿主细胞命运的机制。特别是，我们讨论了铁死亡的作用以及其分子成分如何调节疾病进展。
