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基于家庭的多学科肥胖儿童治疗方案的 5 年随访。

Five-year follow-up of a family-based multidisciplinary program for children with obesity.

机构信息

Liggins Institute, University of Auckland, Auckland, New Zealand.

Department of Paediatrics: Child & Youth Health, School of Medicine, University of Auckland, Auckland, New Zealand.

出版信息

Obesity (Silver Spring). 2021 Sep;29(9):1458-1468. doi: 10.1002/oby.23225. Epub 2021 Aug 9.

Abstract

OBJECTIVE

This study aimed to determine 5-year outcomes from a 12-month, family-based, multidisciplinary lifestyle intervention program for children.

METHODS

This study was the 5-year follow-up of a randomized clinical trial comparing a low-intensity control group (home-based assessments) with a high-intensity intervention group (assessments plus weekly sessions) in New Zealand. Participants were aged 5 to 16 years with BMI ≥ 98th centile or > 91st centile with weight-related comorbidities. The primary outcome was BMI standard deviation score (BMISDS). Secondary outcomes included various health markers.

RESULTS

Of the 199 children included in the study at baseline (47% who identified as Māori, 53% who identified as female, 28% in the most deprived quintile, mean age = 10.7 years, mean BMISDS = 3.12), 86 completed a 5-year assessment (43%). BMISDS reduction at 12 months was not retained (control = 0.00 [95% CI: -0.22 to 0.21] and intervention = 0.17 [95% CI: -0.01 to 0.34]; p = 0.221) but was greater in participants aged <10 years versus >10 years at baseline (-0.15 [95% CI: -0.33 to 0.03] vs. 0.21 [95% CI: 0.03 to 0.40]; p = 0.008). BMISDS trajectory favored participants with high attendance (p = 0.013). There were persistent improvements in water intake and health-related quality of life in both groups as well as reduced sweet drink intake in the intervention group.

CONCLUSIONS

This intervention, with high engagement from those most affected by obesity, did not achieve long-term efficacy of the primary outcome. Attendance and age remain important considerations for future interventions to achieve long-term BMISDS reduction.

摘要

目的

本研究旨在确定一项为期 12 个月的基于家庭的多学科生活方式干预计划对儿童的 5 年结果。

方法

本研究是新西兰一项随机临床试验的 5 年随访,该试验比较了低强度对照组(基于家庭的评估)和高强度干预组(评估加每周会议)。参与者年龄在 5 至 16 岁之间,BMI≥第 98 百分位数或>第 91 百分位数伴有与体重相关的合并症。主要结局指标为 BMI 标准差评分(BMISDS)。次要结局指标包括各种健康指标。

结果

在研究基线时,共有 199 名儿童(47%为毛利人,53%为女性,28%来自最贫困的五分位数,平均年龄=10.7 岁,平均 BMISDS=3.12),其中 86 名完成了 5 年评估(43%)。12 个月时的 BMISDS 降低没有保持(对照组=0.00[95%CI:-0.22 至 0.21]和干预组=0.17[95%CI:-0.01 至 0.34];p=0.221),但在基线时年龄<10 岁的参与者中降低幅度大于年龄>10 岁的参与者(-0.15[95%CI:-0.33 至 0.03]与 0.21[95%CI:0.03 至 0.40];p=0.008)。高出席率的参与者 BMISDS 轨迹更有利(p=0.013)。两组的饮水量和健康相关生活质量均持续改善,干预组的含糖饮料摄入量减少。

结论

这项干预措施得到了受肥胖影响最大的人群的高度参与,但没有实现主要结局的长期疗效。出勤率和年龄仍然是未来干预措施实现长期 BMISDS 降低的重要考虑因素。

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