Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras,Malaysia.
Endocr Metab Immune Disord Drug Targets. 2021;21(12):2273-2280. doi: 10.2174/1871530321666210809154456.
The currently available bone turnover markers are mostly derived from osteoblasts or osteoclasts. Protein markers derived from osteocytes, the most abundant bone cells that can regulate bone turnover activities by other cells, are less explored.
This study aimed to compare the circulating markers of osteocytes and calcium homeostasis between Malaysian postmenopausal women with and without osteoporosis.
Postmenopausal women with (n=20) or without osteoporosis (n=20) as determined by dual- energy X-ray absorptiometry were randomly drawn from a bone health cohort. Their fasting blood was collected and assayed by a multiplex immunoassay panel.
The results showed that osteoprotegerin and sclerostin levels were significantly lower among postmenopausal women with osteoporosis than the normal control. No significant differences in other markers were observed between the two groups. Sclerostin level correlated positively with spine Bone Mineral Density (BMD), while 25-hydroxyvitamin D correlated negatively with hip BMD in the control group. No significant correlation was observed between other markers with spine or hip BMD.
These data provide an insight into the possible roles of osteocyte markers, especially osteoprotegerin and sclerostin, in classifying subjects with osteoporosis. However, the lack of association between these markers and BMD indicates that osteoporosis is a complex and multifactorial condition.
目前可用的骨转换标志物主要来源于成骨细胞或破骨细胞。而骨细胞是含量最丰富的骨细胞，能够通过其他细胞调节骨转换活动，但其来源的蛋白标志物研究较少。
本研究旨在比较马来西亚绝经后骨质疏松症和非骨质疏松症女性之间的循环骨细胞标志物和钙稳态。
从骨健康队列中随机抽取经双能 X 射线吸收仪测定患有（n=20）或未患有（n=20）骨质疏松症的绝经后女性。采集其空腹血样，并用多重免疫分析试剂盒进行检测。
结果显示，与正常对照组相比，骨质疏松症患者的护骨素和硬骨素水平显著降低。两组间其他标志物无显著差异。在对照组中，硬骨素水平与脊柱骨密度（BMD）呈正相关，而 25-羟维生素 D 与髋部 BMD 呈负相关。其他标志物与脊柱或髋部 BMD 之间无显著相关性。
这些数据为骨细胞标志物（尤其是护骨素和硬骨素）在骨质疏松症患者分类中的可能作用提供了新的认识。然而，这些标志物与 BMD 之间缺乏关联表明骨质疏松症是一种复杂的多因素疾病。
