Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Eur J Haematol. 2021 Dec;107(6):595-601. doi: 10.1111/ejh.13696. Epub 2021 Aug 31.
To characterize risk factors for the development of post-transplant erythrocytosis (PTE), and its long-term effect on mortality, graft failure, and thrombosis.
Retrospective study including all kidney transplant recipients in Rabin Medical Center (RMC) during the years 2005-2014. The primary outcome was a composite outcome of all-cause mortality or graft failure at the end of follow-up. Secondary outcomes included death censored graft loss, venous thromboembolism, major adverse cardiovascular events, and mortality. A matched control group was also evaluated. Univariate and multivariate time-varying Cox model analyses were conducted for outcome evaluation.
A total of 1304 patients were included, 169 of whom were diagnosed with PTE (12.9%). PTE was associated with male gender, higher glomerular filtration rate (GFR), and polycystic kidney disease. PTE was found to be associated with a reduced risk of the primary outcome (HR 0.355, CI 95% 0.151-0.89, P = .027) in a univariate time-varying Cox analysis, but was not associated with the composite outcome in a multivariate analysis. There was no difference in the primary outcome when the PTE group was compared with the matched control.
PTE was not found to be associated with long-term outcomes of graft failure and poor survival.
描述移植后红细胞增多症（PTE）发生的危险因素及其对死亡率、移植物衰竭和血栓形成的长期影响。
这是一项回顾性研究，纳入了 2005 年至 2014 年在拉宾医学中心（RMC）接受肾移植的所有患者。主要结局是随访结束时全因死亡率或移植物衰竭的复合结局。次要结局包括死亡相关移植物丢失、静脉血栓栓塞、主要不良心血管事件和死亡率。还评估了匹配的对照组。进行了单变量和多变量时变 Cox 模型分析以评估结局。
共纳入 1304 例患者，其中 169 例诊断为 PTE（12.9%）。PTE 与男性、较高的肾小球滤过率（GFR）和多囊肾病有关。单变量时变 Cox 分析显示，PTE 与主要结局风险降低相关（HR 0.355，95%CI 0.151-0.89，P=0.027），但多变量分析未显示 PTE 与复合结局相关。与匹配对照组相比，PTE 组在主要结局方面没有差异。
PTE 与移植物衰竭和不良生存的长期结局无关。
