Reis Marina, Tavares Joana, Malheiro Jorge, Almeida Manuela, Pedroso Sofia, Dias Leonidio, Henriques António Castro, Cabrita António, Martins La Salete
Nephrology Department, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Nephrology Department, University Hospital Center of Porto, Porto, Portugal.
Transplant Proc. 2023 Jul-Aug;55(6):1411-1415. doi: 10.1016/j.transproceed.2023.03.077. Epub 2023 May 4.
Post-transplant erythrocytosis (PTE) is reported in 8% to 22% of kidney transplant recipients. Few studies have evaluated the prevalence of PTE in simultaneous kidney-pancreas transplantation (SPKT). This study aimed to evaluate the prevalence of PTE in a cohort of SPKT and same-donor single kidney transplant patients and find predictive factors for erythrocytosis development. A single-center retrospective cohort study was performed with 65 SPKT recipients and 65 same-donor single kidney transplant patients. Post-transplant erythrocytosis was defined as a hematocrit persistently >51% without a known cause of erythrocytosis. The PTE prevalence was 23.1% and was more frequent in SPKT patients than in single donor patients (38.5% vs 7.7%; P < .001). The mean time for PTE development was 11.2 ± 13.3 months. In the multivariate model, SPKT was the only predictor for PTE development. De novo hypertension was more frequent in the PTE group (P = .002), but there was no difference in stroke and pancreatic or kidney thrombosis occurrence. Post-transplant erythrocytosis is more common after SPKT than after single kidney transplantation. De novo hypertension was more frequent in the erythrocytosis group, but allograft thrombosis rates.
据报道，8%至22%的肾移植受者会出现移植后红细胞增多症（PTE）。很少有研究评估同期肾胰联合移植（SPKT）中PTE的患病率。本研究旨在评估一组SPKT受者和同供体单肾移植患者中PTE的患病率，并找出红细胞增多症发生的预测因素。对65例SPKT受者和65例同供体单肾移植患者进行了一项单中心回顾性队列研究。移植后红细胞增多症定义为血细胞比容持续>51%且无已知红细胞增多症病因。PTE患病率为23.1%，在SPKT患者中比单供体患者更常见（38.5%对7.7%；P<.001）。PTE发生的平均时间为11.2±13.3个月。在多变量模型中，SPKT是PTE发生的唯一预测因素。新发高血压在PTE组中更常见（P=.002），但中风以及胰腺或肾血栓形成的发生率没有差异。移植后红细胞增多症在SPKT后比单肾移植后更常见。新发高血压在红细胞增多症组中更常见，但同种异体移植血栓形成率……（原文此处似乎不完整）
