Mak J W, Lam P L, Rain A N, Suresh K
Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
J Helminthol. 1987 Dec;61(4):311-4. doi: 10.1017/s0022149x00010221.
Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0.2 mg/kg monthly and two others given 0.3 mg/kg monthly as well as three control animals became patent for microfilaraemia. However, only 1% of the infective dose was recovered as adult worms from animals in the higher drug dosage group compared to 8.2% and 6.2% in the lower dosage and control groups respectively.
四只冠叶猴在每月皮下接种100条感染性幼虫，持续三个月的同时，口服伊维菌素进行治疗。两只每月给予0.2mg/kg药物的动物、两只每月给予0.3mg/kg药物的动物以及三只对照动物均出现了微丝蚴血症。然而，与低剂量组和对照组分别为8.2%和6.2%相比，高剂量药物组动物中仅1%的感染剂量能发育为成虫。
