Taylor J S, Lewis L A, Battle J D, Butkus A, Robertson A L, Deodhar S, Roenigk H H
Arch Dermatol. 1978 Mar;114(3):425-31.
Clinicopathologic findings are reported of a woman with generalized plane xanthoma, multiple myeloma (IgG type K), and hyperlipemia with very high levels of serum cholesterol and triglyceride. Complexing of the serum lipoproteins and immunoglobulins had cryoglobulin properties and was separable by ultracentrifugation. Immunofluorescent studies of skin and bone marrow demonstrated deposits of IgG with low density lipoprotein apoprotein and IgG with beta-lipoprotein, respectively. Although immunosuppressive therapy resulted in return of serum IgG, lipid, and lipoprotein levels to normal, the patient died from the myeloma. Serum lipoprotein-paraprotein complexes have been demonstrated in at least 20 other cases of cutaneous xanthomatosis and myeloma. This interaction may result in an autoimmune hyperlipemia.
报告了一名患有泛发性扁平黄瘤、多发性骨髓瘤（IgG κ型）以及伴有极高血清胆固醇和甘油三酯水平的高脂血症的女性患者的临床病理结果。血清脂蛋白与免疫球蛋白的复合物具有冷球蛋白特性，可通过超速离心分离。皮肤和骨髓的免疫荧光研究分别显示IgG与低密度脂蛋白载脂蛋白以及IgG与β脂蛋白的沉积。尽管免疫抑制治疗使血清IgG、脂质和脂蛋白水平恢复正常，但患者死于骨髓瘤。在至少另外20例皮肤黄瘤病和骨髓瘤病例中已证实存在血清脂蛋白-副蛋白复合物。这种相互作用可能导致自身免疫性高脂血症。
