Mdanda Sipho, Ubanako Philemon, Kondiah Pierre P D, Kumar Pradeep, Choonara Yahya E
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa.
Polymers (Basel). 2021 Jul 22;13(15):2405. doi: 10.3390/polym13152405.
In many clinical applications, the transdermal route is used as an alternative approach to avoid the significant limitations associated with oral drug delivery. There is a long history for drug delivery through the skin utilizing transdermal microneedle arrays. Microneedles are reported to be versatile and very efficient devices. This technique has spurred both industrial and scientific curiosity, due to its outstanding characteristics such as painless penetration, affordability, excellent medicinal efficiency, and relative protection. Microneedles possess outstanding properties for diverse biomedical uses such as the delivery of very large substances with ionic and hydrophilic physicochemical properties. Importantly, microneedles are applicable in numerous biomedical fields such as therapy, diagnosis, and vaccine administration. Microneedles are emerging tools that have shown profound potential for biomedical applications. Transdermal microneedle technologies are likely to become a preferred route of therapeutic substances administration in the future since they are effective, painless, and affordable. In this review, we summarize recent advances in microneedles for therapeutic applications. We explore their constituent materials and fabrication methods that improve the delivery of critical therapeutic substances through the skin. We further discuss the practicality of advanced microneedles used as drug delivery tools.
在许多临床应用中，经皮给药途径被用作一种替代方法，以避免与口服给药相关的重大局限性。利用经皮微针阵列进行皮肤给药已有很长的历史。据报道，微针是多功能且非常有效的装置。由于其无痛穿透、价格实惠、药用效率高和相对保护等突出特性，该技术激发了工业界和科学界的好奇心。微针在多种生物医学用途方面具有出色的性能，例如用于递送具有离子和亲水性物理化学性质的非常大的物质。重要的是，微针适用于众多生物医学领域，如治疗、诊断和疫苗接种。微针是新兴工具，已显示出在生物医学应用中的巨大潜力。经皮微针技术未来可能会成为治疗物质给药的首选途径，因为它们有效、无痛且价格实惠。在本综述中，我们总结了微针在治疗应用方面的最新进展。我们探讨了它们的组成材料和制造方法，这些方法可改善关键治疗物质透过皮肤的递送。我们还进一步讨论了用作药物递送工具的先进微针的实用性。
