Center for Outcomes Research and Economic Evaluation for Health, National Institute of Public Health, Wako, Saitama, Japan.
Department of Health Sciences, Niigata University of Health and Welfare, Kita-ku, Niigata, Japan.
Value Health. 2021 Aug;24(8):1193-1202. doi: 10.1016/j.jval.2021.03.010. Epub 2021 Apr 22.
This study aimed to establish the Japanese population norms of the EQ-5D-5L and Health Utilities Index Mark 3 (HUI3) and estimate the disutility associated with diseases and symptoms.
We performed a door-to-door survey of the general population by random sampling. The planned sample size was 10 000 residents (age ≥16 years) of 334 districts in Japan. In addition to the EQ-5D-5L and HUI3 questionnaires, questions regarding demographic factors and self-reported main diseases and symptoms were asked. The EQ-5D-5L and HUI3 responses were converted to index values on the basis of Japanese value sets. Summary values by age and sex were calculated to obtain Japanese normative values. A multiple linear model was used to examine relationships between these values and diseases and symptoms.
We collected 10 183 responses from 334 districts. The mean EQ-5D-5L index values were 0.821 (male) and 0.774 (female) in the age group of 80 to 89 years, which were lower compared with 0.978 (male) and 0.967 (female) in the age group of 16 to 19 years. Similar trends were observed for the HUI3 values. Age, sex, household income, and education level had a significant influence on the values of both instruments. When measured with the EQ-5D-5L, Parkinson disease, dementia, and stroke were associated with the largest disutility (>0.2), and the disutility for depression was approximately 0.18. In contrast, the HUI3 disutility values for Parkinson disease and dementia were approximately 0.4.
This study established the Japanese population norms of the EQ-5D-5L and HUI3, which can be used in healthcare decision making and contribute to a more reliable analysis of economic evaluations.
本研究旨在建立日本人群 EQ-5D-5L 和健康效用指数 Mark 3（HUI3）的正常值，并估计疾病和症状相关的失能程度。
我们通过随机抽样对日本 334 个地区的一般人群进行了入户调查。计划的样本量为 10000 名（年龄≥16 岁）居民。除了 EQ-5D-5L 和 HUI3 问卷外，还询问了人口统计学因素以及自我报告的主要疾病和症状。根据日本价值体系，将 EQ-5D-5L 和 HUI3 应答转换为指数值。按年龄和性别计算综合值，以获得日本正常值。使用多元线性模型检验这些值与疾病和症状之间的关系。
我们从 334 个地区收集了 10183 份回复。在 80 至 89 岁年龄组中，EQ-5D-5L 指数值男性为 0.821，女性为 0.774，低于 16 至 19 岁年龄组中男性的 0.978 和女性的 0.967。HUI3 值也呈现出类似的趋势。年龄、性别、家庭收入和教育水平对两种工具的数值有显著影响。使用 EQ-5D-5L 进行测量时，帕金森病、痴呆和中风与最大失能（>0.2）相关，而抑郁症的失能约为 0.18。相比之下，帕金森病和痴呆的 HUI3 失能值约为 0.4。
本研究建立了日本人群的 EQ-5D-5L 和 HUI3 正常值，可用于医疗保健决策，并有助于更可靠地分析经济评估。
