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全麻下纤维支气管镜分段肺灌洗治疗肺泡蛋白沉积症并严重呼吸衰竭

Pulmonary Alveolar Proteinosis with Severe Respiratory Failure Improved by Segmental Lung Lavage with Fiberoptic Bronchoscopy under General Anesthesia.

机构信息

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

Department of Respiratory Medicine, Hiroshima University Hospital, Japan.

出版信息

Intern Med. 2022 Feb 1;61(3):389-393. doi: 10.2169/internalmedicine.7432-21. Epub 2021 Aug 6.

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare disorder in which lipoproteinaceous materials accumulate in the alveolar compartments. A 72-year-old man was diagnosed with autoimmune PAP with severe respiratory failure. We decided to perform segmental lung lavage (SLL) with fiberoptic bronchoscopy under general anesthesia. If improvement was not significant, whole-lung lavage (WLL) would be done. SLL improved the respiratory failure and computed tomography findings. This case showed improvement in not only the area where lavage was done but also the non-lavaged area. SLL with fiberoptic bronchoscopy under general anesthesia might be an appropriate treatment option for patients with severe PAP.

摘要

肺泡蛋白沉积症(PAP)是一种罕见的疾病,其中脂蛋白物质在肺泡隔室中积聚。一名 72 岁男性被诊断为自身免疫性 PAP 合并严重呼吸衰竭。我们决定在全身麻醉下进行纤维支气管镜引导下的肺段灌洗(SLL)。如果改善不明显,将进行全肺灌洗(WLL)。SLL 改善了呼吸衰竭和计算机断层扫描的结果。该病例不仅在灌洗部位,而且在非灌洗部位均显示出改善。全身麻醉下纤维支气管镜引导下的 SLL 可能是严重 PAP 患者的一种合适的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/8866800/177880faec12/1349-7235-61-0389-g001.jpg

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