Jeffers G W, Klei T R, Enright F M, Henk W G
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
J Parasitol. 1987 Dec;73(6):1220-33.
A granulomatous inflammatory response develops in jirds with lymphatic or intraperitoneal infections of Brugia pahangi. Light, histochemical, and ultrastructural microscopy were used for comparative studies of the reactions in these 2 locations. The reactions observed were categorized into 3 types: (1) an initial response in which lymphocytes, monocytes, macrophages, and eosinophils were present; (2) an intermediate one which consisted of macrophages, epithelioid cells, lymphocytes, eosinophils, collagen, and mesothelial/endothelial cells with central areas of necrosis; and (3) a terminal reaction consisting of degenerating, necrotic cells. Microfilariae and adult worms were associated with these reactions. Macrophages were the predominant cell type in the lesion and were often found attached to the surface of the parasite. The inflammatory responses to B. pahangi in the lymphatics and in the peritoneal cavity appear to be similar, and thus, the peritoneal cavity may be useful in studying specific cell-parasite interactions to further define the pathogenesis of filarial disease.
感染彭亨布鲁线虫发生淋巴管或腹腔感染的沙鼠会出现肉芽肿性炎症反应。利用光学显微镜、组织化学显微镜和超微结构显微镜对这两个部位的反应进行比较研究。观察到的反应分为3种类型：（1）初始反应，存在淋巴细胞、单核细胞、巨噬细胞和嗜酸性粒细胞；（2）中间反应，由巨噬细胞、上皮样细胞、淋巴细胞、嗜酸性粒细胞、胶原蛋白和间皮/内皮细胞组成，伴有中央坏死区域；（3）终末反应，由退化的坏死细胞组成。微丝蚴和成虫与这些反应相关。巨噬细胞是病变中的主要细胞类型，常发现附着于寄生虫表面。淋巴管和腹腔对彭亨布鲁线虫的炎症反应似乎相似，因此，腹腔可能有助于研究特定的细胞-寄生虫相互作用，以进一步明确丝虫病的发病机制。
