Vincent A L, Ash L R, Rodrick G E, Sodeman W A
J Parasitol. 1980 Aug;66(4):613-20.
We studied the sequence of histopathologic changes associated with Brugia pahangi (Nematoda: Filarioidea) infections in lymphatic vessels in the spermatic cord of the Mongolian jird (gerbil), Meriones unguiculatus. Intravascular granulomas caused mainly by disintegrating worms were seen in 67% of jirds necropsied on, or after, 35 days postinoculation, whereas none of 20 jirds examined before this day showed dying larvae. These granulomas usually evolved without vascular occlusion. Other granulomatous foci, often with a thrombuslike core, sometimes harbored microfilariae or microfilarialike materials. The perilymphatic cellular infiltrate consisted mostly of eosinophils, lymphocytes, and plasma cells. Large numbers of eosinophils were seen in the early weeks, but later declined, while lymphocytes increased to become the predominant cell in old infections. Irregular fibrosis of some valves and portions of the lymphatic walls were seen as early as the 2nd wk postinoculation. Lymphatic changes in the jird are similar to those described in other hosts infected with filariae, but remained moderate. Living worms appeared to be the stimulus for many observed changes. Most pathologic alterations were well established by 3 or 4 mo and showed little qualitative change during the remaining 4 mo of the study.
我们研究了与彭亨布鲁线虫（线虫纲：丝虫总科）感染蒙古沙鼠（长爪沙鼠）精索淋巴管相关的组织病理学变化序列。在接种后35天及以后剖检的沙鼠中，67%可见主要由解体蠕虫引起的血管内肉芽肿，而在此之前检查的20只沙鼠均未发现濒死幼虫。这些肉芽肿通常在无血管阻塞的情况下演变。其他肉芽肿病灶，通常有类似血栓的核心，有时含有微丝蚴或微丝蚴样物质。淋巴管周围细胞浸润主要由嗜酸性粒细胞、淋巴细胞和浆细胞组成。在最初几周可见大量嗜酸性粒细胞，但随后减少，而淋巴细胞增加，在陈旧感染中成为主要细胞。早在接种后第2周就可见一些瓣膜和部分淋巴管壁的不规则纤维化。沙鼠的淋巴变化与其他感染丝虫的宿主中描述的变化相似，但程度较轻。活蠕虫似乎是许多观察到的变化的刺激因素。大多数病理改变在3或4个月时已充分形成，在研究的剩余4个月中几乎没有质的变化。
