Maltsev Dmitrii S, Kulikov Alexei N, Kazak Alina A
Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russian Federation.
Eye (Lond). 2022 Sep;36(9):1795-1798. doi: 10.1038/s41433-021-01736-2. Epub 2021 Aug 9.
To establish the factors responsible for attenuation of the optical coherence tomography (OCT) signal beneath the neurosensory detachment (NSD).
We retrospectively reviewed 33 eyes with acute central serous chorioretinopathy. The thickness of the neurosensory retina, the thickness of the photoreceptor outer segment (PROS) layer, the height of the NSD, and the reflectivity of the underlying retinal pigment epithelium (RPE) were measured at selected points of B-scans exported from 6 × 6 mm OCT angiography protocols. The intensity of the flow signal was measured at the corresponding regions of the choriocapillaris slab. The correlation between the parameters of the NSD and both the reflectivity of underlying RPE and the intensity of the flow signal in the choriocapillaris was calculated.
Correlation coefficients between RPE reflectivity and neurosensory retinal thickness, PROS layer thickness, and NSD height were -0.32, -0.64, and -0.25, respectively (p < 0.001). Correlation coefficients between the intensity of the flow signal and neurosensory retinal thickness, PROS layer thickness, and NSD height were -0.24 (p = 0.004), -0.52 (p < 0.001), and 0.13 (p = 0.13), respectively.
The thickness of the PROS layer is the most significant factor affecting OCT signal at the level of RPE and OCT angiography flow signal in the choriocapillaris beneath the NSD.
确定导致神经感觉层脱离（NSD）下方光学相干断层扫描（OCT）信号衰减的因素。
我们回顾性分析了33例急性中心性浆液性脉络膜视网膜病变患者的眼部情况。在从6×6mm OCT血管造影协议导出的B扫描的选定部位，测量神经感觉视网膜厚度、光感受器外段（PROS）层厚度、NSD高度以及下方视网膜色素上皮（RPE）的反射率。在脉络膜毛细血管层的相应区域测量血流信号强度。计算NSD参数与下方RPE反射率以及脉络膜毛细血管层血流信号强度之间的相关性。
RPE反射率与神经感觉视网膜厚度、PROS层厚度和NSD高度之间的相关系数分别为-0.32、-0.64和-0.25（p<0.001）。血流信号强度与神经感觉视网膜厚度、PROS层厚度和NSD高度之间的相关系数分别为-0.24（p=0.004）、-0.52（p<0.001）和0.13（p=0.13）。
PROS层厚度是影响NSD下方RPE水平的OCT信号以及脉络膜毛细血管层OCT血管造影血流信号的最重要因素。
