Kirsh M M, Behrendt D M, Jackson A P, Dhadphale P, Alseri S, Brymer J, Orringer M B, Sloan H
Ann Thorac Surg. 1978 Feb;25(2):117-21. doi: 10.1016/s0003-4975(10)63503-5.
Twenty-seven patients receiving long-term propranolol therapy underwent myocardial revascularization to relieve stable or unstable angina. The patients were randomly divided into two groups, one (Group 1) in which propranolol was discontinued 48 hours prior to operation and one (Group 2) in which patients received a final dose of propranolol 1 to 2 hours prior to operation. Several physiological variables were compared, and there was no statistically significant difference between the groups except for a slower pulse rate in Group 2 patients. Although the patients in Group 1 showed a greater frequency of hypertension before bypass, the incidence of postoperative complications and perioperative myocardial infarction was the same for both groups. The findings of this study indicate that myocardial revascularization is safe even if propranolol is administered up to 1 or 2 hours before operation.
27名接受长期普萘洛尔治疗的患者接受了心肌血运重建术以缓解稳定型或不稳定型心绞痛。患者被随机分为两组，一组（第1组）在手术前48小时停用普萘洛尔，另一组（第2组）在手术前1至2小时接受普萘洛尔的最后一剂。比较了几个生理变量，除第2组患者脉搏率较慢外，两组之间无统计学显著差异。虽然第1组患者在搭桥术前高血压发生率较高，但两组术后并发症和围手术期心肌梗死的发生率相同。本研究结果表明，即使在手术前1至2小时给予普萘洛尔，心肌血运重建也是安全的。
