Jacquot C, Idatte J M, Bedrossian J, Weiss Y, Safar M, Bariety J
Arch Intern Med. 1978 Feb;138(2):233-6.
Long-term blood pressure changes were studied in 50 patients who had undergone renal homotransplantation. Excluded were those subjects with arterial stenosis of the transplanted kidney, acute or rapidly progressive rejection, or recurrent glomerulonephritis, as well as those retaining their own diseased kidney(s). The blood pressure after the end of the first year was stable and, therefore, was utilized as the reference blood pressure for this study. One year after transplantation, hypertension was observed in 20% of the patients. Mean blood pressure was positively correlated with age (P less than .01), body weight (P less than .001), and serum creatinine level (P less than .001), and negatively correlated with maintenance dose of prednisone (P less than .01). A higher incidence of hypertension was observed in cadaver kidney transplantation than in living related-donor transplantation. The study minimizes the role of glucocorticoids and emphasizes the role of renal factors in the mechanism of the long-term blood pressure changes.
对50例接受同种异体肾移植的患者进行了长期血压变化研究。排除了那些患有移植肾动脉狭窄、急性或快速进展性排斥反应、复发性肾小球肾炎的受试者，以及那些保留自身患病肾脏的受试者。第一年结束后的血压稳定，因此被用作本研究的参考血压。移植后一年，20%的患者出现高血压。平均血压与年龄（P<0.01）、体重（P<0.001）和血清肌酐水平（P<0.001）呈正相关，与泼尼松维持剂量呈负相关（P<0.01）。尸体肾移植中高血压的发生率高于活体亲属供肾移植。该研究将糖皮质激素的作用降至最低，并强调了肾脏因素在长期血压变化机制中的作用。
