Strandgaard S, Hansen U
Br Med J (Clin Res Ed). 1986 Apr 19;292(6527):1041-4. doi: 10.1136/bmj.292.6527.1041.
Evidence for hypertension was sought retrospectively in the necropsy records of 37 cadaveric kidney donors who had died of subarachnoid haemorrhage and 41 donors who had died of head injury, cerebral tumour, or (in a few instances) other causes. Mean relative heart weight in the donors with subarachnoid haemorrhage was 0.58 (1 SD = 0.09)% and in the other donors 0.52 (0.09)% (p less than 0.01), a difference unexplained by any factor other than a comparatively higher blood pressure in the donors who had died of subarachnoid haemorrhage. Blood pressure was analysed over 72 months after renal transplantation in 23 recipients with normal or near normal graft function and no evidence of chronic rejection or graft artery stenosis. Twelve patients who had received kidneys from donors with subarachnoid haemorrhage had consistently higher systolic blood pressures (p less than 0.004) and needed more antihypertensive treatment (p less than 0.0004) than the 11 recipients of kidneys from donors who had died of head injury or cerebral tumour. These observations suggest that cadaveric kidneys from donors dying of subarachnoid haemorrhage may induce or sustain hypertension after transplantation.
在37名死于蛛网膜下腔出血的尸体肾供者以及41名死于头部损伤、脑肿瘤或（少数情况下）其他原因的供者的尸检记录中，对高血压证据进行了回顾性研究。死于蛛网膜下腔出血的供者的平均相对心脏重量为0.58（标准差=0.09）%，其他供者为0.52（0.09）%（p<0.01），除死于蛛网膜下腔出血的供者血压相对较高外，无其他因素可解释这种差异。对23名移植肾功能正常或接近正常且无慢性排斥反应或移植动脉狭窄证据的肾移植受者在肾移植后72个月内的血压进行了分析。与11名接受死于头部损伤或脑肿瘤供者肾脏的受者相比，12名接受死于蛛网膜下腔出血供者肾脏的患者收缩压持续较高（p<0.004），且需要更多的抗高血压治疗（p<0.0004）。这些观察结果表明，死于蛛网膜下腔出血供者的尸体肾可能在移植后诱发或维持高血压。
