Department of Oncology, Affiliated Hospital of Jining Medical University, Zaozhuang Municipal Hospital, Zaozhuang, China.
Department of Obstetrics, Affiliated Hospital of Jining Medical College, Zaozhuang Municipal Hospital, Zaozhuang, China.
Menopause. 2021 Aug 9;28(9):1070-1078. doi: 10.1097/GME.0000000000001806.
Results of this work may provide some guidance for subsequent ovarian cancer screening in women with preeclampsia and provide new directions for future studies.
This study investigated the difference in cancer risk between women with preeclampsia and women with a normal pregnancy.
Electronic databases, namely PubMed, Embase, and the Cochrane Library, were searched for relevant studies from database inception to February 4, 2021. The results are expressed as risk ratios (RRs).
The study included 13 cohort studies comprising 5,254,150 participants. The difference in the total cancer risk between the control and preeclampsia groups was statistically nonsignificant. However, breast cancer (BC) risk was lower in the preeclampsia group (RR = 0.88, 95% confidence interval (CI) = 0.83-0.93; I2 = 57.2%). A subgroup analysis stratified by reproductive factors demonstrated that BC risk in the preeclampsia population decreased in parous women (RR = 0.79, 95% CI = 0.72-0.87; I2 = 0%), women with full-term pregnancies (RR = 0.79, 95% CI = 0.75-0.84; I2 = 0%), and women with increasing parity. Furthermore, BC risk reduced in women with preeclampsia regardless of their menopausal status and the sex of their offspring.
Overall, women with preeclampsia have a decreased BC risk and increased ovarian cancer risk compared with the normal population. A subgroup analysis stratified by reproductive factors demonstrated that BC risk decreased in the preeclampsia population in parous women, women with full-term pregnancies, and women with increasing parity regardless of their menopausal status and the sex of their offspring.
本研究结果可为子痫前期女性后续的卵巢癌筛查提供一定指导，并为未来研究提供新方向。
本研究旨在探讨子痫前期与正常妊娠女性的癌症发病风险差异。
检索了PubMed、Embase 和 Cochrane 图书馆等电子数据库，检索时间从数据库建立至 2021 年 2 月 4 日，纳入的研究结果以风险比（RR）表示。
共纳入 13 项队列研究，包含 5254150 名参与者。对照组与子痫前期组的总癌症发病风险差异无统计学意义。但子痫前期组的乳腺癌（BC）发病风险较低（RR=0.88，95%置信区间[CI]：0.83-0.93；I2=57.2%）。按生殖因素分层的亚组分析显示，经产妇（RR=0.79，95%CI：0.72-0.87；I2=0%）、足月妊娠（RR=0.79，95%CI：0.75-0.84；I2=0%）和经产次增加的子痫前期人群中，BC 发病风险均降低。此外，无论绝经状态和子代性别如何，子痫前期患者的 BC 发病风险均降低。
总体而言，与正常人群相比，子痫前期女性的 BC 发病风险降低，卵巢癌发病风险增加。按生殖因素分层的亚组分析显示，经产妇、足月妊娠和经产次增加的子痫前期人群中，BC 发病风险降低，无论其绝经状态和子代性别如何。
