Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Armed Forces Capital Hospital, Armed Forces Medical Command, Seongnam, Republic of Korea.
Tissue Eng Part C Methods. 2021 Aug;27(8):472-480. doi: 10.1089/ten.TEC.2021.0152.
Although autogenous demineralized dentin matrix (auto-DDM) has shown promising clinical and histological results, it has certain limitations beyond its osteoinductivity and osteoconductivity. Therefore, the application of dentin graft material from other individuals-allogeneic DDM (allo-DDM)-has been considered an alternative to auto-DDM. However, few studies have investigated the osteoinductivity and antigenicity of allo-DDM. Herein, we reviewed all human studies related to allogeneic dentin application for the management of maxillofacial bone defects. Clinical studies have shown the osteoinductivity of allo-DDM in extraskeletal and skeletal sites, regardless of occasional antigenicity. Impact statement Although autogenous demineralized dentin matrix (auto-DDM) has shown promising clinical and histological results, it has certain limitations beyond its proven osteoinductivity and osteoconductivity. Therefore, the application of dentin graft material from other individuals-allogeneic DDM (allo-DDM)-has been considered as an alternative to auto-DDM. However, few studies have investigated the osteoinductivity and antigenicity of allo-DDM. This is the first review of all human studies related to allogeneic dentin grafts for the management of maxillofacial bone defects. Clinical studies have shown the osteoinductivity of allo-DDM in extraskeletal and skeletal sites, regardless of occasional antigenicity.
虽然自体脱矿牙本质基质 (auto-DDM) 在临床和组织学上已显示出良好的效果，但它除了具有成骨诱导性和骨传导性之外，还有一定的局限性。因此，人们考虑使用来自其他个体的牙本质移植物材料——同种异体 DDM (allo-DDM) 作为 auto-DDM 的替代物。然而，很少有研究探讨 allo-DDM 的成骨诱导性和抗原性。本文综述了所有与同种异体牙本质在颌面骨缺损管理中应用相关的人类研究。临床研究表明，allo-DDM 在 extraskeletal 和 skeletal 部位具有成骨诱导性，而不管偶尔存在的抗原性。
