Um In-Woong, Lee Jeong-Keun, Kim Jun-Young, Kim Yu-Mi, Bakhshalian Neema, Jeong Yeong Kon, Ku Jeong-Kui
R&D Institute, Korea Tooth Bank, Seoul 03189, Korea.
Department of Oral and Maxillofacial Surgery, Institute of Oral Health Science, Ajou University School of Medicine, Suwon 16499, Korea.
Materials (Basel). 2021 Mar 31;14(7):1713. doi: 10.3390/ma14071713.
Studies on allogeneic demineralized dentin matrix (Allo-DDM) implantation in the 1960s and 1970s provided the most reliable preclinical evidence of bone formation and antigenicity in an extraosseous site. Recently, applications of Allo-DDM at skeletal sites were studied, and have provided reliable evidence of bone-forming capacity and negligible antigenicity. However, the osteoinductivity and antigenicity properties of Allo-DDM in extraskeletal sites have not yet been investigated due to the lack of follow-up studies after the initial research. The clinical applications of autogenous DDM (Auto-DDM) have been standardized in some countries. Long-term clinical studies have reported the development of several shapes of Auto-DDM, such as powders, blocks, moldable forms, and composites, with recombinant human bone morphogenetic protein-2. For the development of Allo-DDM as a reliable bone graft substitute next to Auto-DDM, we reviewed preclinical studies on the bone induction capacity of allogeneic dentin at extraskeletal as well as skeletal sites. Electronic databases were screened for this review in January 2020 and searched from 1960 to 2019. This review aims to provide a foundation on the preclinical studies of Allo-DDM, which could enable future researches on its osteogenic capability and antigenicity. In conclusion, Allo-DDM showed great potential for osteoinductivity in extraskeletal sites with low antigenicity, which neither adversely affected osteogenic capability nor provoked immunologic reactions. However, the risk of viral disease transmission should be researched before the clinical application of Allo-DDM.
20世纪60年代和70年代关于同种异体脱矿牙本质基质（Allo-DDM）植入的研究提供了在骨外部位骨形成和抗原性最可靠的临床前证据。最近，对Allo-DDM在骨骼部位的应用进行了研究，并提供了骨形成能力和可忽略不计的抗原性的可靠证据。然而，由于初始研究后缺乏随访研究，Allo-DDM在骨外部位的骨诱导性和抗原性特性尚未得到研究。自体DDM（Auto-DDM）的临床应用在一些国家已经标准化。长期临床研究报告了几种形状的Auto-DDM的发展，如粉末、块状、可塑形形式和与重组人骨形态发生蛋白-2的复合材料。为了将Allo-DDM开发成仅次于Auto-DDM的可靠骨移植替代物，我们回顾了关于同种异体牙本质在骨外以及骨骼部位骨诱导能力 的临床前研究。2020年1月对电子数据库进行了筛选以进行本综述，并检索了1960年至2019年的文献。本综述旨在为Allo-DDM的临床前研究提供基础，这可以为其成骨能力和抗原性的未来研究提供支持。总之，Allo-DDM在骨外部位显示出具有低抗原性的强大骨诱导潜力，既不会对成骨能力产生不利影响，也不会引发免疫反应。然而，在Allo-DDM临床应用之前，应研究病毒疾病传播的风险。
