mdx小鼠肌腱-肌连接部的形态学变化
Morphological Changes in the Myotendinous Junction of mdx Mice.
作者信息
Martinez Giovana Zerbo, Grillo Bruna Aléxia Cristofoletti, Rocha Lara Caetano, Jacob Carolina Dos Santos, Pimentel Neto Jurandyr, Tomiate André Neri, Barbosa Gabriela Klein, Watanabe Ii-Sei, Ciena Adriano Polican
机构信息
Laboratory of Morphology and Physical Activity (LAMAF), São Paulo State University (UNESP), Institute of Biosciences (IB), Avenue 24A, n. 1515, Rio Claro, SP 13506-900, Brazil.
Department of Anatomy, Institute of Biomedical Sciences III, University of São Paulo (USP), São Paulo, SP, Brazil.
出版信息
Microsc Microanal. 2021 Aug 11:1-5. doi: 10.1017/S1431927621012496.
The myotendinous junction (MTJ) is the interface between muscle and tendon, and it is the main area of force transmission of the locomotor apparatus. Dystrophic processes promote pathological injury which affects the skeletal muscle and can influence the morphology of the MTJ. This study aimed to investigate the adaptations in MTJ morphology of mdx mice in the tibialis anterior muscle. Male mice (n = 24) were divided into Control—C57bl/10 and mdx—C57bl/10mdx (Duchenne muscular dystrophy experimental model). In the mdx group, centralized nuclei with a large area and greater deposition of type III collagen (fibrosis) were observed. Also, shorter sarcomeres and sarcoplasmatic projections of MTJ were observed. We concluded that the adaptations in mdx mice demonstrated extensive impairment in the MTJ region with reduced ultrastructures.
肌-腱连接（MTJ）是肌肉与肌腱之间的界面，是运动器官力传递的主要区域。营养不良过程会引发影响骨骼肌的病理性损伤，并可能影响MTJ的形态。本研究旨在调查mdx小鼠胫骨前肌MTJ形态的适应性变化。雄性小鼠（n = 24）分为对照组——C57bl/10和mdx组——C57bl/10mdx（杜氏肌营养不良实验模型）。在mdx组中，观察到细胞核集中、面积较大以及III型胶原蛋白沉积增加（纤维化）。此外，还观察到MTJ的肌节较短和肌浆突起。我们得出结论，mdx小鼠的适应性变化表明MTJ区域存在广泛损伤，超微结构减少。
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