儿童期多动/注意力不集中症状轨迹与青少年中期日间皮质醇的关系：来自英国出生队列的研究结果。
Childhood Trajectories of Hyperactivity/Inattention Symptoms and Diurnal Cortisol in Middle Adolescence: Results from a UK Birth Cohort.
机构信息
UCL Institute of Education, London, UK.
出版信息
J Atten Disord. 2022 Apr;26(6):809-821. doi: 10.1177/10870547211036755. Epub 2021 Aug 11.
OBJECTIVE
Children with attention-deficit/hyperactivity disorder (ADHD) show hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether the association between hyperactivity/inattention symptoms with HPA axis dysfunction holds in the general child population too is not clear.
METHOD
We assessed associations between longitudinal trajectories of hyperactivity/inattention symptoms during ages 4 to 13 years and basal cortisol profiles at age 15 in a British general population cohort.
RESULTS
Adolescents with persistently high levels of hyperactivity/inattention symptoms since childhood showed lower total morning cortisol and a smaller diurnal decline, even after adjusting for confounders. No associations were found between any of the symptom trajectories and cortisol awakening response, diurnal slope or daily output of cortisol.
CONCLUSION
This study provides evidence for hypocortisolism among adolescents with chronic hyperactivity/inattention symptoms in the general population.
目的
患有注意缺陷多动障碍（ADHD）的儿童表现出下丘脑-垂体-肾上腺（HPA）轴的低活性。HPA 轴功能障碍与多动/注意力不集中症状之间的关联是否也存在于一般儿童人群中尚不清楚。
方法
我们评估了在英国一般人群队列中，4 至 13 岁期间多动/注意力不集中症状的纵向轨迹与 15 岁时基础皮质醇水平之间的关联。
结果
自儿童期以来一直存在高水平多动/注意力不集中症状的青少年表现出总晨皮质醇水平较低，且昼夜下降幅度较小，即使在调整了混杂因素后也是如此。任何症状轨迹与皮质醇觉醒反应、昼夜斜率或皮质醇日输出之间均无关联。
结论
本研究为一般人群中慢性多动/注意力不集中症状青少年的低皮质醇症提供了证据。
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