用于烯烃自由基氟烷基化反应的氟烷基砜的电化学还原
Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes.
作者信息
Zhou Xin, Ni Chuanfa, Deng Ling, Hu Jinbo
机构信息
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
出版信息
Chem Commun (Camb). 2021 Sep 11;57(70):8750-8753. doi: 10.1039/d1cc03258e. Epub 2021 Aug 10.
Radical fluoroalkylation of alkenes has been developed by electrochemical reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily undergo hydrofluoroalkylation in good to excellent yields. This chemistry represents the first example of electrochemical generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds.
通过氟代烷基砜的电化学还原，已实现了烯烃的自由基氟烷基化反应。一系列缺电子烯烃能够顺利地进行氢氟烷基化反应，产率良好至优异。该化学方法代表了首例由砜电化学生成氟烷基自由基，并将其用于有机化合物实际自由基氟烷基化反应的实例。
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