Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
J Mater Chem B. 2021 Sep 7;9(33):6623-6633. doi: 10.1039/d1tb01097b. Epub 2021 Aug 10.
Cancer treatment has been recently energized by nanomaterials that simultaneously offer diagnostic and therapeutic effects. Among the imaging and treatment modalities in frontline research today, magnetic resonance imaging (MRI) and phototherapy have gained significant interest due to their noninvasiveness among other intriguing benefits. Herein, Fe(iii) was adsorbed on titanium dioxide to develop magnetic Fe-TiO nanocomposites (NCs) which leverage the Fe moiety in a double-edge-sword approach to: (i) achieve T-weighted MRI contrast enhancement, and (ii) improve the well-established photodynamic therapeutic efficacy of TiO nanoparticles. Interestingly, the proposed NCs exhibit classic T MRI contrast agent properties (r = 1.16 mM s) that are comparable to those of clinically available contrast agents. Moreover, the NCs induce negligible cytotoxicity in traditional methods and show remarkable support to the proliferation of intestine organoids, an advanced toxicity evaluation system based on three-dimensional organoids, which could benefit their potential safe application for in vivo cancer theranostics. Aided by the Fenton reaction contribution of the Fe component of the Fe-TiO NCs, considerable photo-killing of cancer cells is achieved upon UV irradiation at very low (2.5 mW cm) intensity in typical cancer PDT. It is therefore expected that this study will guide the engineering of other biocompatible magnetic titania-based nanosystems with multi-faceted properties for biomedical applications.
最近，纳米材料在癌症治疗方面取得了新的进展，这些纳米材料同时具有诊断和治疗效果。在当今前沿研究的成像和治疗方式中，磁共振成像（MRI）和光疗因其非侵入性和其他有趣的优点而引起了极大的兴趣。在此，我们将三价铁吸附到二氧化钛上来制备磁性 Fe-TiO 纳米复合材料（NCs），利用 Fe 部分的双刃剑作用：（i）实现 T 加权 MRI 对比增强，（ii）提高 TiO2 纳米颗粒已建立的光动力治疗效果。有趣的是，所提出的 NCs 表现出典型的 T1 MRI 对比剂特性（r = 1.16 mM s），可与临床可用的对比剂相媲美。此外，NCs 在传统方法中诱导的细胞毒性可忽略不计，并对肠类器官的增殖表现出显著的支持作用，肠类器官是一种基于三维类器官的先进毒性评估系统，这可能有助于它们在体内癌症治疗中的安全应用。Fe-TiO NCs 的 Fe 部分的 Fenton 反应有助于光杀伤癌细胞，在典型的癌症 PDT 中，在非常低（2.5 mW cm）的强度下用紫外线照射就能实现相当程度的光杀伤癌细胞。因此，预计本研究将指导其他具有多功能特性的生物相容性磁性二氧化钛基纳米系统的工程设计，以用于生物医学应用。
