Departamento de Endoscopia, Hospital Universitario, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, BR.
Clinics (Sao Paulo). 2021 Aug 4;76:e2701. doi: 10.6061/clinics/2021/e2701. eCollection 2021.
Pancreatic pseudocysts (PPC) are fluid collections with a well-defined wall that persist for more than 4 weeks inside or around the pancreas as a result of pancreatic inflammation and/or a ductal lesion. PPC have been successfully treated with endoscopic ultrasound (EUS)-guided drainage using different stents. This study aimed to evaluate the safety and efficacy of EUS-guided drainage of PPC using double-pigtail plastic stents in a tertiary hospital.
Patients with PPC referred for EUS-guided drainage between May 2015 and December 2019 were included in this case series. The primary endpoint was to evaluate the efficacy (clinical success) and safety (adverse events and mortality) of EUS-guided drainage of PPC. Secondary endpoints included technical success and pseudocyst recurrence.
Eleven patients (mean age, 44.5±18.98 years) were included in this study. The etiologies for PPC were acute biliary pancreatitis, chronic alcoholic pancreatitis, and blunt abdominal trauma. The mean pseudocyst size was 9.4±2.69 cm. The clinical success rate was 91% (10/11). Adverse events occurred in three of 11 patients (27%). There were no cases of mortality. The technical success rate was 100%. Pseudocyst recurrence was identified in one of 11 patients (9%) at 12 weeks after successful clinical drainage and complete pseudocyst resolution.
EUS-guided transmural drainage of PPC using double-pigtail plastic stents is safe and effective with high technical and clinical success rates.
胰腺假性囊肿（PPC）是一种由于胰腺炎症和/或导管病变导致的在胰腺内或周围持续超过 4 周的具有明确壁的液体聚集物。已经成功地使用不同的支架通过内镜超声（EUS）引导引流来治疗 PPC。本研究旨在评估在一家三级医院使用双猪尾塑料支架进行 EUS 引导引流 PPC 的安全性和疗效。
本病例系列研究纳入了 2015 年 5 月至 2019 年 12 月期间因 EUS 引导引流而转诊的 PPC 患者。主要终点是评估 EUS 引导引流 PPC 的疗效（临床成功率）和安全性（不良事件和死亡率）。次要终点包括技术成功率和假性囊肿复发。
本研究纳入了 11 例患者（平均年龄 44.5±18.98 岁）。PPC 的病因包括急性胆源性胰腺炎、慢性酒精性胰腺炎和钝性腹部外伤。假性囊肿的平均大小为 9.4±2.69cm。临床成功率为 91%（10/11）。11 例患者中有 3 例（27%）发生了不良事件。无死亡病例。技术成功率为 100%。在成功的临床引流和完全假性囊肿消退后 12 周，有 1 例（9%）患者出现假性囊肿复发。
使用双猪尾塑料支架进行 EUS 引导经壁引流 PPC 是安全有效的，具有较高的技术和临床成功率。
