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[慢性炎症性肠病:当新型冠状病毒出现时会发生什么?在摩洛哥非斯哈桑二世大学教学医院进行的一项研究的初步结果(病例报告)]

[Chronic inflammatory bowel diseases: what happens when SARS-CoV-2 occurs? Preliminary results from a study conducted at the Hassan II University Teaching Hospital in Fes, Morocco (a case report)].

作者信息

Abid Hakima, Atmani Imane, Lahmidani Nada, El Yousfi Mounia, Benajah Dafr-Allah, Ibrahimi Sidi Adil, El Abkari Mohamed

机构信息

Service d'Hépato-Gastro-Entérologie, Centre Hospitalier Universitaire Hassan II, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah, Fès, Maroc.

出版信息

Pan Afr Med J. 2021 Apr 19;38:382. doi: 10.11604/pamj.2021.38.382.27235. eCollection 2021.

Abstract

SARS-CoV-2 infection is a major concern and a new threat to immunocompromised patients. Patients with chronic inflammatory bowel diseases (IBDs) are at increased risk of infections, in particular when they have active disease and are on immunosuppressive treatment. The purpose of this study was to assess the clinical, biological and radiological features of three patients with COVID-19 associated with chronic IBD as well as their management and outcomes. The study was conducted at the Hassan II University Teaching Hospital in Fes, Morocco over a 3-month period. We assessed all patients with disease onset. All patients had mild symptoms or were asymptomatic. No changes or delays in treatment regimens occurred and none of patients developed severe COVID-19. Reverse transcription polymerase chain reaction (RT-PCR) test results were positive in all patients. Radiological examinations were conducted. Chest scanner showed ground-glass opacities in one case. Treatment was based on hydroxychloroquine with azithromycin. Outcome was good in all cases. This preliminary report suggests that patients with chronic IBD aren't at higher risk of developing COVID-19 compared to the general population.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染是免疫功能低下患者面临的主要问题和新威胁。患有慢性炎症性肠病(IBD)的患者感染风险增加,尤其是在他们患有活动性疾病且正在接受免疫抑制治疗时。本研究的目的是评估三名与慢性IBD相关的新型冠状病毒肺炎(COVID-19)患者的临床、生物学和放射学特征,以及他们的治疗和结局。该研究在摩洛哥非斯的哈桑二世大学教学医院进行,为期3个月。我们评估了所有发病患者。所有患者症状轻微或无症状。治疗方案未发生变化或延迟,且无一例患者发展为重症COVID-19。所有患者的逆转录聚合酶链反应(RT-PCR)检测结果均为阳性。进行了放射学检查。胸部扫描仪检查显示1例出现磨玻璃影。治疗以羟氯喹联合阿奇霉素为基础。所有病例结局良好。这份初步报告表明,与普通人群相比,慢性IBD患者发生COVID-19的风险并不更高。

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