评价在泰国接受门诊家庭化疗的结直肠癌患者的不良事件和与健康相关的生活质量。
Evaluation of adverse events and health-related quality of life in patients with colorectal cancer receiving ambulatory home-based chemotherapy in Thailand.
机构信息
Department of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Department of Nursing, Somdech Phra Debaratana Medical Center Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Nurs Open. 2021 Nov;8(6):3036-3044. doi: 10.1002/nop2.1016. Epub 2021 Aug 12.
AIMS
To compare adverse events and health-related quality of life in ambulatory home-based chemotherapy with those in inpatient.
DESIGN
Prospective non-randomized observational study.
METHODS
Participants were divided into two groups according to patients' preference receiving chemotherapy.
RESULTS
Sixty-four participants were enrolled in the inpatient, and 111 were in an ambulatory home-based chemotherapy. The frequency of anaemia, neutropenia and thrombocytopenia was significantly higher in inpatient group than in ambulatory home-based chemotherapy group (p < .001, <.001 and .002, respectively). Nausea, mucositis, and fatigue were more common in ambulatory home-based chemotherapy group than in inpatient group (p < .001, .022, and .005, respectively). Patients in the ambulatory home-based chemotherapy group showed higher social well-being (SWB) scores than inpatient group (coefficient 1.92, 95% confidence interval [CI] 0.65 to 3.19, p .003).
目的
比较门诊家庭化疗与住院化疗的不良事件和健康相关生活质量。
设计
前瞻性非随机观察性研究。
方法
根据患者的偏好，将参与者分为两组接受化疗。
结果
64 名参与者被纳入住院组，111 名参与者被纳入门诊家庭化疗组。住院组贫血、中性粒细胞减少和血小板减少的发生率明显高于门诊家庭化疗组（p<0.001、<.001 和<.002，分别）。恶心、黏膜炎和疲劳在门诊家庭化疗组比住院组更常见（p<0.001、<.022 和<.005，分别）。门诊家庭化疗组的患者比住院组的患者具有更高的社会福利（SWB）评分（系数 1.92，95%置信区间 [CI] 0.65 至 3.19，p<.003）。
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