Tsai Chin-Shiang, Hung Yuan-Pin, Lee Jen-Chieh, Syue Ling-Shan, Hsueh Po-Ren, Ko Wen-Chien
Department of Internal Medicine, National Cheng Kung University Hospital, Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan.
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Expert Rev Anti Infect Ther. 2021 Dec;19(12):1543-1552. doi: 10.1080/14787210.2021.1967746. Epub 2021 Aug 23.
infection (CDI) is the most common cause of antibiotic-associated diarrhea and one of the common infections in healthcare facilities. In recent decades, there has been an emerging threat of community-acquired CDI (CA-CDI). Environmental transmission of in the community setting has become a major concern, and animals are an important reservoir for causing human diseases.
In this article, the molecular epidemiology of in animals and recent evidences of zoonotic transfer to humans are reviewed based on an electronic search in the databases of PubMed and Google Scholar.
can be found in stool from diarrheal dogs and cats; therefore, household pets could be a potential source. will threaten human health because hypervirulent ribotype 078 strains have been found in retail chickens, pig farms, and slaughterhouses. Risk factors for fecal carriage in animals include young age, dietary changes, and antibiotic abuse in domestic animals. With the advent of whole genome sequencing techniques, there will be more solid evidence indicating zoonotic transfer of from animals to humans.
艰难梭菌感染(CDI)是抗生素相关性腹泻最常见的病因,也是医疗机构中常见的感染之一。近几十年来,社区获得性CDI(CA-CDI)出现了新的威胁。在社区环境中艰难梭菌的环境传播已成为主要关注点,动物是导致人类疾病的艰难梭菌的重要储存宿主。
本文基于在PubMed和谷歌学术数据库中的电子检索,综述了动物中艰难梭菌的分子流行病学以及人畜共患传播给人类的最新证据。
在腹泻猫狗的粪便中可发现艰难梭菌;因此,家养宠物可能是一个潜在来源。由于在零售鸡肉、养猪场和屠宰场中发现了高毒力的078型艰难梭菌菌株,艰难梭菌将威胁人类健康。动物粪便携带艰难梭菌的风险因素包括年龄小、饮食变化以及家畜抗生素滥用。随着全基因组测序技术的出现,将有更多确凿证据表明艰难梭菌从动物向人类的人畜共患传播。