Jo Han-Gue, Shin Nara
School of Computer Information and Communication Engineering, Kunsan National University, Gunsan, Korea.
Human Rights Center, Konkuk University, Seoul, Korea.
Healthc Inform Res. 2021 Jul;27(3):249-254. doi: 10.4258/hir.2021.27.3.249. Epub 2021 Jul 31.
Changes in the autonomic nervous system have been observed in patients with depressive disorders by measuring their heart rate variability (HRV). However, whether HRV associates with depressive events in healthy people remains unknown.
Four healthy people participated in the present study. Their HRVs were measured routinely for 6 to 13 months. During this time, two participants reported experiencing two and three bouts of depression, respectively. This approach allowed us to examine changes in the participants' HRVs by comparing their HRVs from before and after the unexpected depressive events. Changes in HRV were compared against those of two participants who did not report any depressive event.
Participants' low frequency/high frequency (LF/HF) ratios of HRV were lower after the event of depression than before. Their LF/HF ratios increased after recovery from the depressive events. In contrast, two participants who did not report any depressive event showed relatively smaller changes in their LF/HF ratios across measurements.
These results suggest that the LF/HF ratio may provide an objective measure of subjective experiences of depression and help identify potential cases of clinical depression.
通过测量心率变异性（HRV），已观察到抑郁症患者自主神经系统的变化。然而，HRV是否与健康人的抑郁事件相关仍不清楚。
四名健康人参与了本研究。对他们的HRV进行了6至13个月的常规测量。在此期间，两名参与者分别报告经历了两次和三次抑郁发作。这种方法使我们能够通过比较意外抑郁事件前后参与者的HRV来检查其HRV的变化。将HRV的变化与两名未报告任何抑郁事件的参与者的变化进行比较。
抑郁事件发生后，参与者HRV的低频/高频（LF/HF）比值低于事件前。从抑郁事件恢复后，他们的LF/HF比值增加。相比之下，两名未报告任何抑郁事件的参与者在各次测量中其LF/HF比值的变化相对较小。
这些结果表明，LF/HF比值可能为抑郁的主观体验提供一种客观测量方法，并有助于识别潜在的临床抑郁症病例。
