Department of Immunology and Microbiology, Shanghai JiaoTong University, School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China.
Department of Immunology and Microbiology, Shanghai JiaoTong University, School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China.
Cell Immunol. 2021 Oct;368:104421. doi: 10.1016/j.cellimm.2021.104421. Epub 2021 Aug 6.
Epigallocatechin-3 gallate (EGCG) is a polyphenolic component of tea and has potential curative effects in patients with autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS). It remains unknown whether EGCG can regulate macrophage subtypes in MS. Here we evaluated the effects of EGCG in experimental autoimmune encephalomyelitis (EAE), MS mouse model. We found that EGCG treatment reduced EAE severity and macrophage inflammation in the CNS. Moreover, EAE severity was well correlated with the ratio of M1 to M2 macrophages, and EGCG treatment suppressed M1 macrophage-mediated inflammation in spleen. In vitro experiments showed that EGCG inhibited M1 macrophage polarization, but promoted M2 macrophage polarization. These effects were likely to be related to the inhibition of nuclear factor-κB signaling and glycolysis in macrophages by EGCG in macrophages. Overall, these findings provided important insights into the mechanisms through which EGCG may mediate MS.
没食子酸表没食子儿茶素酯（EGCG）是茶叶中的一种多酚成分，对自身免疫性疾病患者具有潜在的治疗效果。多发性硬化症（MS）是一种影响中枢神经系统（CNS）的自身免疫性疾病。目前尚不清楚 EGCG 是否可以调节 MS 中的巨噬细胞亚型。在这里，我们评估了 EGCG 在实验性自身免疫性脑脊髓炎（EAE）、MS 小鼠模型中的作用。我们发现 EGCG 治疗可降低 EAE 的严重程度和中枢神经系统中的巨噬细胞炎症。此外，EAE 的严重程度与 M1 与 M2 巨噬细胞的比例密切相关，EGCG 治疗可抑制脾脏中 M1 巨噬细胞介导的炎症。体外实验表明，EGCG 抑制 M1 巨噬细胞极化，但促进 M2 巨噬细胞极化。这些作用可能与 EGCG 在巨噬细胞中抑制核因子-κB 信号和糖酵解有关。总的来说，这些发现为 EGCG 可能介导 MS 的机制提供了重要的见解。
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