Nishie Miyuki, Masaki Katsunori, Okuzumi Shinichi, Mochimaru Takao, Kabata Hiroki, Miyata Jun, Takahashi Hayato, Fukunaga Koichi
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Keio Allergy Center, Keio University Hospital, Tokyo, Japan.
Asia Pac Allergy. 2021 Jul 9;11(3):e27. doi: 10.5415/apallergy.2021.11.e27. eCollection 2021 Jul.
Food allergy is a typical immediate-onset allergic disease in which symptoms are provoked by exposure to the sensitized antigens. Although previous reports have shown that omalizumab has helped children with egg or milk allergy achieve oral immunotherapy safely, there is still no established method for induction of remission in adult food allergy. A 51-year-old woman with oral steroid-dependent severe asthma was treated with omalizumab for 6 years. She had shellfish and wheat food allergy and oral allergy syndrome induced by kiwi and other foods associated with latex-fruit syndrome. Since omalizumab treatment, her food allergy symptoms had disappeared. After 7 years of this treatment, disseminated erythema suddenly appeared; omalizumab was discontinued because of suspected drug-induced eruption. After omalizumab interruption, she felt an itching sensation in her throat with worsened asthma control immediately after wheat ingestion. Readministration of omalizumab improved these symptoms. Thus, we raised the possibility that omalizumab not only improved asthma control but also induced pharmacological remission of the patient's food allergy. Omalizumab may be considered as a treatment option for adult patients with food allergies and severe asthma.
食物过敏是一种典型的速发型过敏性疾病，其症状由接触致敏抗原引发。尽管先前的报告显示奥马珠单抗已帮助患有鸡蛋或牛奶过敏的儿童安全地实现口服免疫疗法，但成人食物过敏的诱导缓解方法仍未确立。一名51岁依赖口服类固醇的重度哮喘女性接受了6年的奥马珠单抗治疗。她对贝类和小麦过敏，并且对猕猴桃及其他与乳胶 - 水果综合征相关的食物引发口腔过敏综合征。自接受奥马珠单抗治疗以来，她的食物过敏症状消失。在这种治疗7年后，突然出现了弥漫性红斑；由于怀疑药物性皮疹，停用了奥马珠单抗。奥马珠单抗中断后，她在摄入小麦后立即感到喉咙瘙痒，哮喘控制恶化。重新使用奥马珠单抗改善了这些症状。因此，我们提出奥马珠单抗不仅改善了哮喘控制，还诱导了患者食物过敏的药理学缓解的可能性。奥马珠单抗可被视为患有食物过敏和重度哮喘的成年患者的一种治疗选择。
