食物过敏
Food Allergy.
作者信息
Iweala Onyinye I, Choudhary Shailesh K, Commins Scott P
机构信息
Department of Medicine and Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Thurston Research Center, Division of Allergy, Immunology and Rheumatology, University of North Carolina, 3300 Thurston Building, CB 7280, Chapel Hill, NC, 27599-7280, USA.
出版信息
Curr Gastroenterol Rep. 2018 Apr 5;20(5):17. doi: 10.1007/s11894-018-0624-y.
Abstract
PURPOSE OF REVIEW
The goal of this review is to present an updated summary of the natural history of major childhood and adult food allergies and report recent advances in potential treatments for food allergy.
RECENT FINDINGS
The most common childhood food allergies are typically outgrown by adolescence or adulthood. However, peanut/tree nut allergies appear to more commonly persist into adulthood. Adults can develop new IgE-mediated food allergies; the most common is oral allergy syndrome. There are multiple different approaches being tried as possible treatments for food allergy. The prevalence of food allergy appears to be increasing but the varied approaches to treatment are being actively pursued such that an approved modality may not be too far in the future.
摘要
综述目的
本综述的目的是提供一份关于儿童和成人主要食物过敏自然史的最新总结，并报告食物过敏潜在治疗方法的最新进展。
最新发现
最常见的儿童食物过敏通常在青春期或成年期自愈。然而，花生/坚果过敏似乎更常持续到成年期。成年人可发生新的IgE介导的食物过敏；最常见的是口腔过敏综合征。目前正在尝试多种不同方法作为食物过敏的可能治疗方法。食物过敏的患病率似乎在上升，但各种治疗方法正在积极探索，因此未来不久可能会有一种获批的治疗方式。
相似文献
1
Food Allergy.食物过敏
Curr Gastroenterol Rep. 2018 Apr 5;20(5):17. doi: 10.1007/s11894-018-0624-y.
2
Current Status of Potential Therapies for IgE-Mediated Food Allergy.IgE 介导的食物过敏潜在疗法的现状。
Curr Allergy Asthma Rep. 2018 Feb 22;18(3):18. doi: 10.1007/s11882-018-0772-z.
3
Oral immunotherapy and tolerance induction in childhood.儿童口服免疫治疗和耐受诱导。
Pediatr Allergy Immunol. 2013 Sep;24(6):512-20. doi: 10.1111/pai.12100. Epub 2013 Aug 2.
4
Review article: the diagnosis and management of food allergy and food intolerances.综述文章：食物过敏和食物不耐受的诊断与管理
Aliment Pharmacol Ther. 2015 Jan;41(1):3-25. doi: 10.1111/apt.12984. Epub 2014 Oct 14.
5
Food allergy: immune mechanisms, diagnosis and immunotherapy.食物过敏：免疫机制、诊断与免疫疗法。
Nat Rev Immunol. 2016 Dec;16(12):751-765. doi: 10.1038/nri.2016.111. Epub 2016 Oct 31.
6
Targeting IgE to facilitate oral immunotherapy for food allergy: a potential new role for anti-IgE therapy?靶向IgE以促进食物过敏的口服免疫疗法：抗IgE疗法的潜在新作用？
Expert Rev Clin Immunol. 2014 Sep;10(9):1125-8. doi: 10.1586/1744666X.2014.948849.
7
Current and Emerging Therapies for IgE-Mediated Food Allergy.IgE 介导的食物过敏的当前和新兴疗法。
Curr Allergy Asthma Rep. 2016 Apr;16(4):28. doi: 10.1007/s11882-016-0610-0.
8
Food Allergy.食物过敏
Med Clin North Am. 2024 Jul;108(4):655-670. doi: 10.1016/j.mcna.2023.08.003.
9
Update on Potential Therapies for IgE-Mediated Food Allergy.IgE 介导的食物过敏潜在治疗方法的最新进展。
Curr Allergy Asthma Rep. 2017 Jan;17(1):4. doi: 10.1007/s11882-017-0671-8.
10
Food allergy: epidemiology and natural history.食物过敏：流行病学与自然史
Immunol Allergy Clin North Am. 2015 Feb;35(1):45-59. doi: 10.1016/j.iac.2014.09.004. Epub 2014 Nov 21.
引用本文的文献
1
A Review of Alpha-Gal Syndrome for the Infectious Diseases Practitioner.传染病医生对α-半乳糖综合征的综述
Open Forum Infect Dis. 2025 Jul 21;12(8):ofaf430. doi: 10.1093/ofid/ofaf430. eCollection 2025 Aug.
2
Human umbilical cord-derived mesenchymal stem cells attenate histaminergic effect of intestinal mucosa through bax/bcl-2 pathway in food allergic enteritis.人脐带间充质干细胞通过bax/bcl-2途径减轻食物过敏性肠炎中肠黏膜的组胺能效应。
Sci Rep. 2025 May 26;15(1):18442. doi: 10.1038/s41598-025-03563-x.
3
Food allergens in immune systems.免疫系统中的食物过敏原。
Food Sci Biotechnol. 2025 Jan 7;34(10):2079-2085. doi: 10.1007/s10068-024-01772-0. eCollection 2025 Jun.
4
Exploring the potential link between vegetable oil supplementation and adverse food reactions in dogs: a preliminary study.探索植物油补充剂与犬类不良食物反应之间的潜在联系：一项初步研究。
BMC Vet Res. 2025 Apr 14;21(1):269. doi: 10.1186/s12917-025-04720-0.
5
Synergistic Synbiotic-Containing and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein.含协同合生元和低聚果糖可减轻大豆蛋白诱导的小鼠过敏反应。
Foods. 2025 Jan 2;14(1):109. doi: 10.3390/foods14010109.
6
Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.全基因组关联研究揭示过敏性鼻炎与榛子过敏之间的因果关系。
Allergy. 2025 Jan;80(1):309-318. doi: 10.1111/all.16411. Epub 2024 Dec 14.
7
Pyroptosis, gasdermins and allergic diseases.细胞焦亡、gasdermin 家族蛋白与变应性疾病
Allergy. 2024 Sep;79(9):2380-2395. doi: 10.1111/all.16236. Epub 2024 Jul 14.
8
A murine model of peanut-allergic asthma.花生过敏性哮喘的小鼠模型。
Front Allergy. 2024 Apr 25;5:1378877. doi: 10.3389/falgy.2024.1378877. eCollection 2024.
9
Differences in the Course, Diagnosis, and Treatment of Food Allergies Depending on Age-Comparison of Children and Adults.食物过敏的病程、诊断和治疗的差异取决于年龄——儿童与成人的比较。
Nutrients. 2024 Apr 27;16(9):1317. doi: 10.3390/nu16091317.
10
Micronutrients in infants suffering from cow's milk allergy fed with dietary formulas and breast milk.患有牛奶过敏的婴儿在食用配方食品和母乳时的微量营养素。
BMC Pediatr. 2024 Feb 13;24(1):115. doi: 10.1186/s12887-024-04591-8.
本文引用的文献
1
Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial.不同剂量表皮免疫疗法与安慰剂对花生敏感患者花生蛋白暴露反应的影响：一项随机临床试验。
JAMA. 2017 Nov 14;318(18):1798-1809. doi: 10.1001/jama.2017.16591.
2
Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults.用于治疗儿童和青年花生过敏的经皮免疫疗法。
J Allergy Clin Immunol. 2017 Apr;139(4):1242-1252.e9. doi: 10.1016/j.jaci.2016.08.017. Epub 2016 Oct 26.
3
Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.对花生过敏的学龄前儿童进行早期口服免疫疗法是安全且高效的。
J Allergy Clin Immunol. 2017 Jan;139(1):173-181.e8. doi: 10.1016/j.jaci.2016.05.027. Epub 2016 Aug 10.
4
Occupational contact urticaria caused by food - a systematic clinical review.食物引起的职业性接触性荨麻疹——一项系统的临床综述
Contact Dermatitis. 2016 Oct;75(4):195-204. doi: 10.1111/cod.12653. Epub 2016 Jul 18.
5
[Food allergy in adulthood].[成人食物过敏]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Jun;59(6):737-44. doi: 10.1007/s00103-016-2360-5.
6
Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness.鸡蛋口服免疫治疗期间IgA、IgE和IgG4的成分解析分析确定了与持续无反应相关的标志物。
Allergy. 2016 Nov;71(11):1552-1560. doi: 10.1111/all.12895. Epub 2016 Jun 13.
7
Safety of epicutaneous immunotherapy for the treatment of peanut allergy: A phase 1 study using the Viaskin patch.经皮免疫疗法治疗花生过敏的安全性：一项使用Viaskin贴片的1期研究。
J Allergy Clin Immunol. 2016 Apr;137(4):1258-1261.e10. doi: 10.1016/j.jaci.2016.01.008. Epub 2016 Feb 24.
8
Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial.花生过敏的舌下免疫疗法：一项随机多中心试验的长期随访
J Allergy Clin Immunol. 2015 May;135(5):1240-8.e1-3. doi: 10.1016/j.jaci.2014.12.1917. Epub 2015 Feb 3.
9
Prevalence and characteristics of adult-onset food allergy.成人期食物过敏的患病率及特征
J Allergy Clin Immunol Pract. 2015 Jan-Feb;3(1):114-5.e1. doi: 10.1016/j.jaip.2014.07.007. Epub 2014 Aug 29.
10
Food allergy preceded by contact urticaria due to the same food: involvement of epicutaneous sensitization in food allergy.由相同食物引起的接触性荨麻疹先于食物过敏：经皮致敏在食物过敏中的作用。
Allergol Int. 2015 Jan;64(1):73-8. doi: 10.1016/j.alit.2014.08.005. Epub 2014 Oct 28.
Zotero 插件