Bell T A, Sandström K I, Gravett M G, Mohan K, Kuo C C, Stamm W E, Eschenbach D A, Chandler J W, Holmes K K, Foy H M
Department of Epidemiology, University of Washington, Seattle 98195.
Sex Transm Dis. 1987 Oct-Dec;14(4):195-200. doi: 10.1097/00007435-198710000-00003.
During prospective studies of infants born vaginally to women with cervical Chlamydia trachomatis infection, we evaluated 27 infants given 0.5% erythromycin ointment and 93 given 1% silver nitrate solution as eye prophylaxis, according to the preference of the parents or delivery room personnel. The cumulative proportion of infants developing chlamydial conjunctivitis was 25% for both groups (P = 0.37, Mantel-Cox test). The cumulative proportion of infants developing chlamydial infection at any anatomic site was 74% for those given erythromycin and 70% for those given silver nitrate (P = 0.93). The two groups did not differ significantly in cumulative proportions developing nonchlamydial conjunctivitis. These results indicate that, as it is routinely used in our hospital, erythromycin ointment was not more effective than silver nitrate as prophylaxis against chlamydial conjunctivitis. The influence of delayed administration on efficacy of prophylaxis requires further evaluation.
在对沙眼衣原体感染的孕妇经阴道分娩的婴儿进行前瞻性研究时，我们根据父母或产房工作人员的偏好，对27名接受0.5%红霉素眼膏和93名接受1%硝酸银溶液进行眼部预防的婴儿进行了评估。两组中发生衣原体结膜炎的婴儿累积比例均为25%（曼特尔 - 考克斯检验，P = 0.37）。接受红霉素治疗的婴儿在任何解剖部位发生衣原体感染的累积比例为74%，接受硝酸银治疗的婴儿为70%（P = 0.93）。两组在发生非衣原体结膜炎的累积比例上无显著差异。这些结果表明，在我们医院常规使用的情况下，红霉素眼膏作为预防衣原体结膜炎的效果并不比硝酸银更好。延迟给药对预防效果的影响需要进一步评估。
