Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
Department of Research, Etiological Research Unit, Cancer Registry of Norway, Oslo, Norway.
PLoS One. 2021 Aug 13;16(8):e0253944. doi: 10.1371/journal.pone.0253944. eCollection 2021.
On February 26th 2020, a high alert was issued in Sweden in response to the diagnosis of the first few coronavirus disease 2019 (COVID-19) cases in the country. Subsequently, a decreased supply of essential goods, including medical products, was anticipated. We aimed to explore the weekly patterns of prescription dispensing and over-the-counter (OTC) medication sales in Sweden in 2020 compared with previous years, to assess the influence of the government restrictions on medication sales, and to assess whether there is evidence of medication stockpiling in the population.
Aggregated data on the weekly volume of defined daily doses (DDDs) of prescription medication dispensed and OTC sales from 2015 to 2020 were examined. From 2015-2019 data, the predicted weekly volume of DDDs for 2020 was estimated and compared to the observed volume for each ATC anatomical main group and therapeutic subgroup.
From mid-February to mid-March 2020, there were increases in the weekly volumes of dispensed medication, peaking in the second week of March with a 46% increase in the observed versus predicted number of DDDs dispensed (16,440 vs 11,260 DDDs per 1000 inhabitants). A similar pattern was found in all age groups, in both sexes, and across metropolitan and non-metropolitan regions. In the same week in March, there was a 96% increase in the volume of OTC sold (2,504 vs 1,277 DDDs per 1000 inhabitants), specifically in ATC therapeutic subgroups including vitamins, antipyretics, painkillers, and nasal, throat, cough and cold preparations.
Beginning in mid-February 2020, there were significant changes in the volume of prescription medication dispensed and OTC drugs sold. The weekly volume of DDDs quickly decreased following recommendations from public authorities. Overall, our findings suggest stockpiling behavior over a surge in new users of medication.
2020 年 2 月 26 日,瑞典发布了高级警报,以应对该国首批几例新型冠状病毒病(COVID-19)病例的诊断。随后,预计包括医疗产品在内的基本商品供应将会减少。我们旨在探讨 2020 年瑞典与前几年相比,处方配药和非处方(OTC)药物销售的每周模式,以评估政府对药物销售限制的影响,并评估人群中是否有药物囤积的证据。
研究了 2015 年至 2020 年每周处方药和 OTC 销售的定义日剂量(DDD)总量汇总数据。根据 2015-2019 年的数据,估计了 2020 年每周 DDD 的预计总量,并将其与每个 ATC 解剖主要组和治疗亚组的观察总量进行了比较。
从 2 月中旬到 3 月中旬,配药的每周量增加,3 月第二周达到峰值,观察到的 DDD 配药数量比预测数量增加了 46%(每 1000 名居民 16440 对 11260 DDD)。所有年龄组、性别以及大都市和非大都市地区都出现了类似的模式。在 3 月的同一周,OTC 销售量增加了 96%(每 1000 名居民 2504 对 1277 DDD),特别是在包括维生素、解热药、止痛药以及鼻、喉、咳嗽和感冒制剂在内的 ATC 治疗亚组。
从 2020 年 2 月中旬开始,处方药和 OTC 药物的配药量发生了显著变化。在公共卫生当局的建议下,DDD 的每周总量迅速减少。总的来说,我们的发现表明,在新的药物使用者激增的情况下存在囤货行为。