Department of Blood Transfusion, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Lab Med. 2022 Jan 6;53(1):65-70. doi: 10.1093/labmed/lmab062.
The purpose of this study was to determine whether circular RNA hsa_circ_0002874 could serve as a novel biomarker for the diagnosis of gastric cancer (GC). The expression level of hsa_circ_0002874 mean (interquartile range [IQR]) in the plasma of patients with GC, patients with benign gastric lesions, and healthy individuals was 3.482 (IQR, 1.524-9.048), 1.261 (IQR, 0.817-2.000), and 1.00 (IQR, 0.726-1.382), respectively, whereas there was no significant difference between the latter 2 groups. The plasma expression level of hsa_circ_0002874 was significantly correlated with tumor stage (U = 234.0; P < .001) and lymph node metastasis (U = 240.0; P < .001). The receiver operating characteristic (ROC) curve showed that the sensitivity of the combined determination of hsa_circ_0002874 and the serum markers CEA and CA19-9 was 95.8% in patients with GC compared with that of the healthy group and 93.0% compared with that of patients with benign gastric tumor lesions. The specificity of hsa_circ_0002874 in differentiating GC from benign lesions was 98.3%. The results showed that plasma hsa_circ_0002874 may prove to be a useful biomarker for auxiliary diagnosis, the grading of malignant neoplasms, and the prognostic prediction of GC.
本研究旨在探讨环状 RNA hsa_circ_0002874 是否可作为胃癌（GC）诊断的新型生物标志物。GC 患者、良性胃部病变患者和健康个体的血浆 hsa_circ_0002874 表达水平分别为 3.482（IQR，1.524-9.048）、1.261（IQR，0.817-2.000）和 1.00（IQR，0.726-1.382），后两组间无显著差异。hsa_circ_0002874 的血浆表达水平与肿瘤分期（U=234.0；P<.001）和淋巴结转移（U=240.0；P<.001）显著相关。受试者工作特征（ROC）曲线显示，与健康组相比，hsa_circ_0002874 联合检测血清标志物 CEA 和 CA19-9 对 GC 患者的检测灵敏度为 95.8%，与良性胃部肿瘤病变患者相比为 93.0%。hsa_circ_0002874 区分 GC 与良性病变的特异性为 98.3%。结果表明，血浆 hsa_circ_0002874 可能成为辅助诊断、恶性肿瘤分级和 GC 预后预测的有用生物标志物。
