The First Clinical Medical College, Lanzhou University, Lanzhou, China.
The First Clinical Medical College, Lanzhou University, Lanzhou, China; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Biomed Pharmacother. 2021 Oct;142:111990. doi: 10.1016/j.biopha.2021.111990. Epub 2021 Aug 10.
Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation, chemical synthesis and biotransformation from birch. BA has antitumour activity, and its mechanisms of action mainly include the induction of mitochondrial oxidative stress; the regulation of specificity protein transcription factors, and the inhibition of signal transducer and activator of transcription 3 and nuclear factor-κB signalling pathways. In addition, BA can increase the sensitivity of cancer cells to other chemotherapy drugs. Recent studies have shown that BA plays an anticancer role in several kinds of tumour diseases. In this article, the anticancer mechanism of BA and its application in the treatment of tumour diseases are reviewed.
白桦脂酸（BA）是一种五环三萜类化合物，可从桦木中通过分离、化学合成和生物转化获得。BA 具有抗肿瘤活性，其作用机制主要包括诱导线粒体氧化应激；调节特异性蛋白转录因子，抑制信号转导和转录激活因子 3 和核因子-κB 信号通路。此外，BA 可以提高癌细胞对其他化疗药物的敏感性。最近的研究表明，BA 在几种肿瘤疾病中发挥抗癌作用。本文综述了 BA 的抗癌机制及其在肿瘤疾病治疗中的应用。
