Department of Internal Medicine, Mercy St Vincent Medical Center, Toledo, Ohio, USA
Department of Pathology, Mercy Saint Vincent Medical Center, Toledo, Ohio, USA.
BMJ Case Rep. 2021 Aug 13;14(8):e242851. doi: 10.1136/bcr-2021-242851.
Systemic sclerosis (SSc) is a rare connective tissue disorder with a complex pathogenesis involving vascular dysfunction, small vessel proliferation as well as alterations of innate and adaptive immunity. Gastrointestinal (GI) involvement in SSc is almost universal and affects nearly 90% of the patients. Of all the GI manifestations, 30%-75% are oesophageal abnormalities, including gastro-oesophageal reflux disease, reflux oesophagitis and Barret's oesophagus. The incidence of gastric manifestations is about 22% with a common presentation of gastric antral vascular ectasia (GAVE). However, autoimmune atrophic gastritis (AIG) is not a known manifestation of SSc. Our case has a unique presentation of the coexistence of GAVE and AIG. We have conducted a thorough literature review to study a possible association of AIG and SSc and understand the pathology of SSc.
系统性硬化症（SSc）是一种罕见的结缔组织疾病，其发病机制复杂，涉及血管功能障碍、小血管增殖以及固有和适应性免疫的改变。SSc 几乎会累及胃肠道（GI），近 90%的患者会受到影响。在所有的 GI 表现中，30%-75%为食管异常，包括胃食管反流病、反流性食管炎和巴雷特食管。胃表现的发生率约为 22%，常见的表现为胃底静脉曲张（GAVE）。然而，自身免疫性萎缩性胃炎（AIG）并不是 SSc 的已知表现。我们的病例具有 GAVE 和 AIG 共存的独特表现。我们进行了彻底的文献回顾，以研究 AIG 和 SSc 之间可能的关联，并了解 SSc 的病理学。
