系统性硬化症中的自身免疫性萎缩性胃炎。
Autoimmune atrophic gastritis in systemic sclerosis.
机构信息
Department of Internal Medicine, Mercy St Vincent Medical Center, Toledo, Ohio, USA
Department of Pathology, Mercy Saint Vincent Medical Center, Toledo, Ohio, USA.
出版信息
BMJ Case Rep. 2021 Aug 13;14(8):e242851. doi: 10.1136/bcr-2021-242851.
Systemic sclerosis (SSc) is a rare connective tissue disorder with a complex pathogenesis involving vascular dysfunction, small vessel proliferation as well as alterations of innate and adaptive immunity. Gastrointestinal (GI) involvement in SSc is almost universal and affects nearly 90% of the patients. Of all the GI manifestations, 30%-75% are oesophageal abnormalities, including gastro-oesophageal reflux disease, reflux oesophagitis and Barret's oesophagus. The incidence of gastric manifestations is about 22% with a common presentation of gastric antral vascular ectasia (GAVE). However, autoimmune atrophic gastritis (AIG) is not a known manifestation of SSc. Our case has a unique presentation of the coexistence of GAVE and AIG. We have conducted a thorough literature review to study a possible association of AIG and SSc and understand the pathology of SSc.
系统性硬化症（SSc）是一种罕见的结缔组织疾病，其发病机制复杂，涉及血管功能障碍、小血管增殖以及固有和适应性免疫的改变。SSc 几乎会累及胃肠道（GI），近 90%的患者会受到影响。在所有的 GI 表现中，30%-75%为食管异常，包括胃食管反流病、反流性食管炎和巴雷特食管。胃表现的发生率约为 22%，常见的表现为胃底静脉曲张（GAVE）。然而，自身免疫性萎缩性胃炎（AIG）并不是 SSc 的已知表现。我们的病例具有 GAVE 和 AIG 共存的独特表现。我们进行了彻底的文献回顾，以研究 AIG 和 SSc 之间可能的关联，并了解 SSc 的病理学。
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