Torregrossa Marta, Kakpenova Ainur, Simon Jan C, Franz Sandra
Department of Dermatology, Venerology and Allergology, Max Bürger Research Centre, Leipzig University, Johannisallee 30, D-04103 Leipzig, Germany.
Biol Chem. 2021 Aug 16;402(11):1289-1307. doi: 10.1515/hsz-2021-0145. Print 2021 Oct 26.
Nonhealing chronic wounds are among the most common skin disorders with increasing incidence worldwide. However, their treatment is still dissatisfying, that is why novel therapeutic concepts targeting the sustained inflammatory process have emerged. Increasing understanding of chronic wound pathologies has put macrophages in the spotlight of such approaches. Herein, we review current concepts and perspectives of therapeutic macrophage control by ECM-inspired wound dressing materials. We provide an overview of the current understanding of macrophage diversity with particular view on their roles in skin and in physiological and disturbed wound healing processes. Based on this we discuss strategies for their modulation in chronic wounds and how such strategies can be tailored in ECM-inspired wound dressing. The latter utilize and mimic general principles of ECM-mediated cell control, such as binding and delivery of signaling molecules and direct signaling to cells specifically adapted for macrophage regulation in wounds. In this review, we present examples of most recent approaches and discuss ideas for their further development.
难愈合慢性伤口是全球发病率不断上升的最常见皮肤疾病之一。然而，其治疗效果仍不尽人意，这就是为什么针对持续性炎症过程的新型治疗理念应运而生。对慢性伤口病理学的深入了解使巨噬细胞成为此类治疗方法的焦点。在此，我们综述了受细胞外基质（ECM）启发的伤口敷料材料对巨噬细胞进行治疗性调控的当前概念和前景。我们概述了目前对巨噬细胞多样性的理解，特别关注它们在皮肤以及生理和紊乱伤口愈合过程中的作用。在此基础上，我们讨论了在慢性伤口中调节巨噬细胞的策略，以及如何在受ECM启发的伤口敷料中定制此类策略。后者利用并模仿ECM介导的细胞控制的一般原理，如信号分子的结合和递送以及直接向专门适应伤口巨噬细胞调节的细胞发出信号。在本综述中，我们展示了最新方法的实例，并讨论了其进一步发展的思路。
