Vasil'ev A V, Shimanovskaia N P, Pogozheva A V, Samsonov M A, Tutel'ian V A
Vopr Pitan. 1987 Nov-Dec(6):14-7.
Investigation of lysosomal hydrolase activity in platelets of patients has revealed drastic activation of cathepsins B, C and phospholipase A1, the degree of which rose in the following range: coronary heart disease; coronary heart disease aggravated by obesity: obesity and hyperlipidemia (type II). Administration of the adequate dietotherapy resulted in normalization of enzymologic parameters, whereas the results of the clinico-biochemical analysis of the blood were less informative in all cases. The data obtained could be used in the evaluation of the dietotherapy effectiveness, as well as for the early diagnosis of the corresponding diseases.
对患者血小板中溶酶体水解酶活性的研究表明，组织蛋白酶B、C和磷脂酶A1有显著激活，其激活程度在以下范围内上升：冠心病；因肥胖加重的冠心病；肥胖症和高脂血症（II型）。采用适当的饮食疗法可使酶学参数恢复正常，而血液的临床生化分析结果在所有情况下提供的信息较少。所获得的数据可用于评估饮食疗法的效果，以及相应疾病的早期诊断。
