Tabagari S I, Feofilaktova S N, Varsanovich E A, Vasil'ev A V, Tutel'ian V A
Vopr Med Khim. 1990 Nov-Dec;36(6):32-4.
Activity of cathepsins D, B, C, H, L, acid lipase, acid cholesterol ester hydrolase, phospholipase A1, A2 and glucuronidase were studied in liver, small intestinal mucosa, intimal aortic cells, blood platelets and monocyte of rabbit after oral administration of cholesterol at daily dose of 300 mg/kg body weight within 100 days. Under this conditions distinct changes functional state of lysosomal systems were found in liver, monocyte and intima aortic cells. A possible mechanism of observed enzymological changes is discussed.
在给兔子每日口服300毫克/千克体重的胆固醇，持续100天后，研究了其肝脏、小肠黏膜、主动脉内膜细胞、血小板和单核细胞中组织蛋白酶D、B、C、H、L、酸性脂肪酶、酸性胆固醇酯水解酶、磷脂酶A1、A2和葡萄糖醛酸酶的活性。在这种情况下，发现肝脏、单核细胞和主动脉内膜细胞的溶酶体系统功能状态有明显变化。讨论了观察到的酶学变化的可能机制。
