Marsál K, Furgyik S
Department of Obstetrics and Gynaecology, Malmö General Hospital, Sweden.
Acta Obstet Gynecol Scand. 1987;66(7):653-6. doi: 10.3109/00016348709022074.
Zinc deficiency was reported to lead to congenital malformations and abnormal fetal development, and zinc concentration in amniotic fluid has been found to be correlated with fetal birth weight. In the present study, zinc concentrations were estimated in 8 pregnant women at 15 gestational weeks and 68 pregnant women at term. Maternal serum zinc concentration in early and term pregnancy was significantly lower than that of the non-pregnant controls (mean values +/- SEM being 9.8 +/- 0.6, 9.3 +/- 0.2, and 11.5 +/- 0.3 mumol/l, respectively). Maternal serum zinc concentrations reached the non-pregnant level by one week post partum. The mean serum zinc concentration in cord blood was 14.4 (+/- 0.4) mumol/l. The zinc concentration in the amniotic fluid was very low both in early pregnancy and at term 1.1 and 0.8 mumol/l, respectively, and no correlation was found to the birth weight. Low serum zinc content in pregnant women occurs as a normal feature and congenital malformation as a consequence of disturbed zinc metabolism is probably only to be seen in instances of extreme zinc deficiency in conjunction with malnutrition.
据报道，锌缺乏会导致先天性畸形和胎儿发育异常，并且已发现羊水中的锌浓度与胎儿出生体重相关。在本研究中，对8名孕15周的孕妇和68名足月孕妇的锌浓度进行了评估。孕早期和足月时孕妇血清锌浓度显著低于未怀孕对照组（平均值±标准误分别为9.8±0.6、9.3±0.2和11.5±0.3μmol/L）。产后一周孕妇血清锌浓度达到未怀孕时的水平。脐血中血清锌浓度平均值为14.4（±0.4）μmol/L。孕早期和足月时羊水中的锌浓度都非常低，分别为1.1和0.8μmol/L，且与出生体重无相关性。孕妇血清锌含量低是一种正常特征，因锌代谢紊乱导致的先天性畸形可能仅在极端锌缺乏并伴有营养不良的情况下才会出现。
