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社会保障机构所治疗人群中经实验室确诊的新冠病毒再次感染情况

Laboratory-confirmed SARS-CoV-2 reinfection in the population treated at social security.

作者信息

Santiago-Espinosa Oscar, Prieto-Torres María Erandhi, Cabrera-Gaytán David Alejandro

机构信息

Instituto Mexicano del Seguro Social. Coordinación de Información y Análisis Estratégico. Av. Politécnico, entre Tepich y Knic SM 509, Manzana 1, Lote 1. CP. 077533. Cancún, Quintana Roo. México.

Instituto Mexicano del Seguro Social. Coordinación de Investigación en Salud. Av. Cuauhtémoc # 330, Bloque "B" 4° piso, Anexo a la Unidad de Congresos del Centro Médico Nacional Siglo XXI, Col. Doctores, Alcaldía Cuauhtémoc, CP. 06720, Ciudad de México, México.

出版信息

Respir Med Case Rep. 2021;34:101493. doi: 10.1016/j.rmcr.2021.101493. Epub 2021 Aug 9.

Abstract

The scientific community has questioned whether reinfection with SARS-CoV-2 is possible. Gradually, cases of reinfection have been documented. In Mexico, people with SARS-CoV-2 reinfection have not been officially identified. To allow a retrospective investigation of patients with PCR-confirmed SARS-CoV-2 and to identify how reinfected with this virus occurs in a population that requires medical attention. A retrospective search of the epidemiological surveillance system was performed to identify people who met the clinical criteria based on laboratory diagnosis of SARS-CoV-2 and temporality to identify cases of reinfection. Clinical information was collected from clinical records. Seven people with two separate COVID-19 events were identified in medical units in Quintana Roo, Mexico between April and December 2020. The overall median interval between the two events was 156 days (61-191 days). Six people were health workers, and one was a member of the general population. This is one of the first reports of reinfection in health personnel in Mexico, revealing that the frequency of reinfection is low among positive cases and that the interval between infection episodes was three months. There are several scenarios in the natural history of the disease that must be considered based on adequate anamnesis with a clinical-epidemiological approach to determine the correct diagnostic category.

摘要

科学界对再次感染新型冠状病毒(SARS-CoV-2)是否可能存在质疑。逐渐地,再次感染的病例已有记录。在墨西哥,尚未正式确认有再次感染SARS-CoV-2的人员。为了对经聚合酶链反应(PCR)确诊感染SARS-CoV-2的患者进行回顾性调查,并确定在需要医疗护理的人群中该病毒再次感染是如何发生的。我们对流行病学监测系统进行了回顾性检索,以识别那些基于SARS-CoV-2实验室诊断和时间顺序符合临床标准的人员,从而确定再次感染病例。临床信息从临床记录中收集。2020年4月至12月期间,在墨西哥金塔纳罗奥州的医疗机构中,我们识别出7名经历了两次独立的新型冠状病毒肺炎(COVID-19)事件的人员。两次事件之间的总体中位间隔时间为156天(61 - 191天)。其中6人为医护人员,1人为普通人群。这是墨西哥关于医护人员再次感染的首批报告之一,表明在阳性病例中再次感染的频率较低,且感染发作之间的间隔为三个月。基于充分的既往史,采用临床流行病学方法,在疾病的自然史中有几种情况必须予以考虑,以确定正确的诊断类别。

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